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BMS-P5

CAS No. 1549811-36-0

BMS-P5( —— )

Catalog No. M27535 CAS No. 1549811-36-0

BMS-P5 is a specific and orally active Peptidylarginine Deiminase 4 (PAD4) inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BMS-P5
  • Note
    Research use only, not for human use.
  • Brief Description
    BMS-P5 is a specific and orally active Peptidylarginine Deiminase 4 (PAD4) inhibitor.
  • Description
    BMS-P5 is a specific and orally active Peptidylarginine Deiminase 4 (PAD4) inhibitor.
  • In Vitro
    BMS-P5 blocks calcium ionophore-induced citrullination of histone H3.BMS-P5 is also able to inhibit formation of NETs induced by primary MM cells isolated from the BM of patients with MM. Cell Viability Assay Cell Line:Neutrophils.Concentration:10 μM and 100 μM.Incubation Time:30 min followed by addition of DP42 or 5TGM1 CM.Result:Prevented MM-induced NET formation.
  • In Vivo
    BMS-P5 (50 mg/kg, oral gavage) significantly improves survival of MM-bearing mice.BMS-P5 (50 mg/kg, oral gavage) may attenuate the presence of pro-tumorigenic proteins in the tumor microenvironment, and thus delay tumor progression. Animal Model:Syngeneic mouse model of MM.Dosage:50 mg/kg.Administration:Oral gavage, twice a day beginning on day 3 after tumor cell injection.Result:Significantly delayed development of symptoms and significantly prolonged survival of MM-bearing mice.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    COX|HO-1|NOS|Nrf2|PKC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1549811-36-0
  • Formula Weight
    509.04
  • Molecular Formula
    C27H33ClN6O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CC(OC)=C2C(N=C(N2C)C3=CC4=CC=CN=C4N3CC5CC5)=C1)N6[C@H](CC[C@H](C6)N)C.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Nam JW, et al. Heat shock factor 1 inducers from the bark of Eucommia ulmoides as cytoprotective agents. Chem Biodivers. 2013 Jul;10(7):1322-7.
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