BMS-986251

CAS No. 2041841-30-7

BMS-986251 ( —— )

Catalog No. M21869 CAS No. 2041841-30-7

BMS-986251 is a Clinically Viable, Potent, and Selective RORγt Inverse Agonist. BMS-986251 displayed dose-dependent inhibition of IL-17F production in a mouse IL-2/IL-23 stimulated pharmacodynamic model.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BMS-986251
  • Note
    Research use only, not for human use.
  • Brief Description
    BMS-986251 is a Clinically Viable, Potent, and Selective RORγt Inverse Agonist. BMS-986251 displayed dose-dependent inhibition of IL-17F production in a mouse IL-2/IL-23 stimulated pharmacodynamic model.
  • Description
    BMS-986251 is a Clinically Viable, Potent, and Selective RORγt Inverse Agonist. BMS-986251 displayed dose-dependent inhibition of IL-17F production in a mouse IL-2/IL-23 stimulated pharmacodynamic model. BMS-986251 was studied in mouse acanthosis and imiquimod-induced models of skin inflammation, where it demonstrated robust efficacy comparable to a positive control.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2041841-30-7
  • Formula Weight
    667.61
  • Molecular Formula
    C30H29F8NO5S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    FC(C(F)(F)F)(C(F)(F)F)C1=CC2=C(C=C1)[C@@]3(S(=O)(C4=CC=C(F)C=C4)=O)[C@@](N(C([C@@H]5CC[C@@H](C(O)=O)C[C@@H]5C)=O)CC3)([H])CC2
  • Chemical Name
    (1R,3S,4R)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)- 2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-3-methylcyclohexane-1-carboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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