BMS-986251( —— )

Catalog No. M21869 CAS No. 2041841-30-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BMS-986251
Note

Research use only, not for human use.
Brief Description

BMS-986251 is a Clinically Viable, Potent, and Selective RORγt Inverse Agonist.
Description

BMS-986251 is a Clinically Viable, Potent, and Selective RORγt Inverse Agonist. BMS-986251 displayed dose-dependent inhibition of IL-17F production in a mouse IL-2/IL-23 stimulated pharmacodynamic model. BMS-986251 was studied in mouse acanthosis and imiquimod-induced models of skin inflammation, where it demonstrated robust efficacy comparable to a positive control.
In Vitro

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In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

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Research Area

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Indication

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CAS Number

2041841-30-7
Formula Weight

667.61
Molecular Formula

C30H29F8NO5S
Purity

>98% (HPLC)
Solubility

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SMILES

FC(C(F)(F)F)(C(F)(F)F)C1=CC2=C(C=C1)[C@@]3(S(=O)(C4=CC=C(F)C=C4)=O)[C@@](N(C([C@@H]5CC[C@@H](C(O)=O)C[C@@H]5C)=O)CC3)([H])CC2
Chemical Name

(1R,3S,4R)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)- 2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-3-methylcyclohexane-1-carboxylic acid