BMS-919373 ( BMS919373 )

Catalog No. M11139 CAS No. 1272353-82-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BMS-919373
Note

Research use only, not for human use.
Brief Description

BMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM.
Description

BMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM, with selectivity versus hERG, Na, Ca channels and reduced the level of brain penetration; shows robust anti- arrhythmia effects in rabbit and canine pharmacodynamic models and an acceptable cross-species pharmacokinetic profile.Heart Arrhythmia Phase 1 Discontinued
Synonyms

BMS919373
Pathway

Cell Cycle/DNA Damage
Target

Potassium Channel
Recptor

Potassium Channel
Research Area

Cardiovascular Disease
Indication

Heart Arrhythmia

CAS Number

1272353-82-8
Formula Weight

468.54
Molecular Formula

C25H20N6O2S
Purity

>98% (HPLC)
Solubility

——
SMILES

C1=CC=C(C=C1)C2=C3C(=CC=C2)N=C(N=C3NCC4=CC=CC=N4)C5=CC(=CN=C5)S(=O)(=O)N
Chemical Name

5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridine-3-sulfonamide

1. Gunaga P, et al. J Med Chem. 2017 May 11;60(9):3795-3803.

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