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Home - Products - Cell Cycle/DNA Damage - Potassium Channel - BMS-919373

BMS-919373

CAS No. 1272353-82-8

BMS-919373( BMS919373 )

Catalog No. M11139 CAS No. 1272353-82-8

BMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 1161 Get Quote
25MG 1755 Get Quote
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Biological Information

  • Product Name
    BMS-919373
  • Note
    Research use only, not for human use.
  • Brief Description
    BMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM.
  • Description
    BMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM, with selectivity versus hERG, Na, Ca channels and reduced the level of brain penetration; shows robust anti- arrhythmia effects in rabbit and canine pharmacodynamic models and an acceptable cross-species pharmacokinetic profile.Heart Arrhythmia Phase 1 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BMS919373
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    Cardiovascular Disease
  • Indication
    Heart Arrhythmia

Chemical Information

  • CAS Number
    1272353-82-8
  • Formula Weight
    468.535
  • Molecular Formula
    C25H20N6O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1=CC=C(C=C1)C2=C3C(=CC=C2)N=C(N=C3NCC4=CC=CC=N4)C5=CC(=CN=C5)S(=O)(=O)N
  • Chemical Name
    5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridine-3-sulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gunaga P, et al. J Med Chem. 2017 May 11;60(9):3795-3803.
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