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BMS-599626
CAS No. 714971-09-2
BMS-599626 ( BMS599626;AC480;BMS 599626;AC-480;AC 480 )
Catalog No. M15733 CAS No. 714971-09-2
A potent, selective inhibitor of EGFR and HER2 with IC50 of 20 nM and 30 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 57 | Get Quote |
|
| 5MG | 103 | Get Quote |
|
| 25MG | 340 | Get Quote |
|
| 50MG | 437 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBMS-599626
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective inhibitor of EGFR and HER2 with IC50 of 20 nM and 30 nM.
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DescriptionA potent, selective inhibitor of EGFR and HER2 with IC50 of 20 nM and 30 nM; displays 8-fold less potency to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc; inhibits the proliferation of tumor cells expressing high levels of HER1 and/or HER2; shows potent antitumor activity in a human breast tumor KPL-4 xenograft; orally efficacious.Breast Cancer Phase 1 Discontinued
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SynonymsBMS599626;AC480;BMS 599626;AC-480;AC 480
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PathwayAngiogenesis
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TargetEGFR
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RecptorHER1;HER2;HER4;Lck;MEK
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Research AreaCancer
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IndicationBreast Cancer
Chemical Information
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CAS Number714971-09-2
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Formula Weight530.55
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Molecular FormulaC27H27FN8O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(OC[C@H]1NCCOC1)NC2=CN3N=CN=C(NC4=CC5=C(N(CC6=CC=CC(F)=C6)N=C5)C=C4)C3=C2C
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Chemical Name(S)-morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gavai AV, et al. J Med Chem. 2009 Nov 12;52(21):6527-30.
2. Wong TW, et al. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6186-93.
3. Haluska P, et al. Mol Cancer Ther. 2008 Sep;7(9):2589-98.
2. Wong TW, et al. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6186-93.
3. Haluska P, et al. Mol Cancer Ther. 2008 Sep;7(9):2589-98.
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