BMS-536924 ( BMS536924; BMS-536924; BMS 536924 )

Catalog No. M17514 CAS No. 468740-43-4

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Product Name

BMS-536924
Note

Research use only, not for human use.
Brief Description

BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.
Description

BMS-536924 is a potent small molecule inhibitor of IGF-IR, which shows antitumor activity in multiple tumor models, including sarcoma.
Synonyms

BMS536924; BMS-536924; BMS 536924
Pathway

Others
Target

Other Targets
Recptor

FAK; IGF-1R; Insulin Receptor; MEK; Lck
Research Area

Cancer
Indication

——

CAS Number

468740-43-4
Formula Weight

479.96
Molecular Formula

C25H26ClN5O3
Purity

98%
Solubility

DMSO : 50 mg/mL. 104.18 mM; H2O : < 0.1 mg/mL
SMILES

CC1=C2N=C(NC2=CC(=C1)N1CCOCC1)C1=C(NC[C@@H](O)C2=CC=CC(Cl)=C2)C=CNC1=O
Chemical Name

(S)-4-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one

1. Wittman M, et al. J Med Chem, 2005, 48(18), 5639-5643.

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