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BMS-536924
CAS No. 468740-43-4
BMS-536924 ( BMS536924; BMS-536924; BMS 536924 )
Catalog No. M17514 CAS No. 468740-43-4
BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 67 | In Stock |
|
| 10MG | 116 | In Stock |
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| 25MG | 232 | In Stock |
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| 50MG | 446 | In Stock |
|
| 100MG | 597 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBMS-536924
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NoteResearch use only, not for human use.
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Brief DescriptionBMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.
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DescriptionBMS-536924 is a potent small molecule inhibitor of IGF-IR, which shows antitumor activity in multiple tumor models, including sarcoma.
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SynonymsBMS536924; BMS-536924; BMS 536924
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PathwayOthers
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TargetOther Targets
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RecptorFAK; IGF-1R; Insulin Receptor; MEK; Lck
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number468740-43-4
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Formula Weight479.96
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Molecular FormulaC25H26ClN5O3
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Purity98%
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SolubilityDMSO : 50 mg/mL. 104.18 mM; H2O : < 0.1 mg/mL
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SMILESCC1=C2N=C(NC2=CC(=C1)N1CCOCC1)C1=C(NC[C@@H](O)C2=CC=CC(Cl)=C2)C=CNC1=O
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Chemical Name(S)-4-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wittman M, et al. J Med Chem, 2005, 48(18), 5639-5643.
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