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BMS-502

CAS No. 2407854-18-4

BMS-502( —— )

Catalog No. M37109 CAS No. 2407854-18-4

BMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ that induces immune responses in human and mouse T cells and blocks intracellular checkpoint signaling in T cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 192 Get Quote
5MG 297 Get Quote
10MG 464 Get Quote
25MG 753 Get Quote
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Biological Information

  • Product Name
    BMS-502
  • Note
    Research use only, not for human use.
  • Brief Description
    BMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ that induces immune responses in human and mouse T cells and blocks intracellular checkpoint signaling in T cells.
  • Description
    BMS-502 (Compound 22) is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 of 4.6 nM and 2.1 nM. BMS-502 enhanced T cell immune responses in mice. BMS-502 can be used in tumor immunity related research.
  • In Vitro
    ——
  • In Vivo
    Animal Model:OT-1 mouse model Dosage:0-10 mg/kg Administration:Oral administration; 24 h Result:Caused no significant increase in activated effector T-cells.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2407854-18-4
  • Formula Weight
    516.5
  • Molecular Formula
    C27H22F2N6O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (193.61 mM; Ultrasonic (<80°C)
  • SMILES
    N#CC1=NC2=C(N(C)C(C([N+]([O-])=O)=C2N3CCN(C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)CC3)=O)C=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chupak L, et al. Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization. ACS Med Chem Lett. 2023 Jun 12;14(7):929-935.?
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