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BMS-502
CAS No. 2407854-18-4
BMS-502( —— )
Catalog No. M37109 CAS No. 2407854-18-4
BMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ that induces immune responses in human and mouse T cells and blocks intracellular checkpoint signaling in T cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 192 | Get Quote |
|
| 5MG | 297 | Get Quote |
|
| 10MG | 464 | Get Quote |
|
| 25MG | 753 | Get Quote |
|
| 50MG | 994 | Get Quote |
|
| 100MG | 1341 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBMS-502
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NoteResearch use only, not for human use.
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Brief DescriptionBMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ that induces immune responses in human and mouse T cells and blocks intracellular checkpoint signaling in T cells.
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DescriptionBMS-502 (Compound 22) is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 of 4.6 nM and 2.1 nM. BMS-502 enhanced T cell immune responses in mice. BMS-502 can be used in tumor immunity related research.
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In Vitro——
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In VivoAnimal Model:OT-1 mouse model Dosage:0-10 mg/kg Administration:Oral administration; 24 h Result:Caused no significant increase in activated effector T-cells.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2407854-18-4
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Formula Weight516.5
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Molecular FormulaC27H22F2N6O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (193.61 mM; Ultrasonic (<80°C)
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SMILESN#CC1=NC2=C(N(C)C(C([N+]([O-])=O)=C2N3CCN(C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)CC3)=O)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chupak L, et al. Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization. ACS Med Chem Lett. 2023 Jun 12;14(7):929-935.?
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