BK-1361

CAS No. 1975145-82-4

BK-1361( BK 1361 | BK1361 | cyclo-RLsKDK )

Catalog No. M21713 CAS No. 1975145-82-4

BK-1361(BK1361, cyclo-RLsKDK) is a cyclic peptide with RLsKDK (s=D-serine) that functions as a potent, selective inhibitor of ADAM8 with IC50 of 120 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BK-1361
  • Note
    Research use only, not for human use.
  • Brief Description
    BK-1361(BK1361, cyclo-RLsKDK) is a cyclic peptide with RLsKDK (s=D-serine) that functions as a potent, selective inhibitor of ADAM8 with IC50 of 120 nM.
  • Description
    BK-1361(BK1361, cyclo-RLsKDK) is a cyclic peptide with RLsKDK (s=D-serine) that functions as a potent, selective inhibitor of ADAM8 with IC50 of 120 nM; displays no significant activity against ADAM 9, 10, 12, 17 , as well as MMP-2, -9, and -14 at 10 uM; inhibit shedding of CD23 with IC50 of 182 nM in cell-based shedding assays, reduces migration/invasion of pancreatic cancer cells and less ERK1/2 and MMP activation, causes change in cell morphology; decreases tumour burden and metastasis of implanted pancreatic tumour cells and provides improved metrics of clinical symptoms and survival in Kras(G12D)-driven mouse model of PDAC.
  • In Vitro
    Cell Invasion Assay Cell Line:Panc1_A8 cells.Concentration:10, 100 and 1,000?nM.Incubation Time:6?h.Result:Reduced cell invasion with dose-dependent manner.
  • In Vivo
    ——
  • Synonyms
    BK 1361 | BK1361 | cyclo-RLsKDK
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1975145-82-4
  • Formula Weight
    727.86
  • Molecular Formula
    C31H57N11O9
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yim V, et al. Bioorg Med Chem. 2016 Sep 15;24(18):4032-4037.
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