BIX02188

Research use only, not for human use.

BIX02188 is a potent, selective inhibitor of MEK5 catalytic activity with IC50 of 4.3 nM.

BIX02188 is a potent, selective inhibitor of MEK5 catalytic activity with IC50 of 4.3 nM, wekaly inhibits ERK5 catalytic activity (IC50=810 nM) and does not inhibits closely related kinases MEK1, MEK2, ERK2, and JNK2; blocks phosphorylation of ERK5, without affecting phosphorylation of ERK1/2 in sorbitol-stimulated HeLa cells, also inhibits transcriptional activation of MEF2C, a downstream substrate of the MEK5/ERK5 signaling cascade, in a cellular trans-reporter assay system; induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD.

BIX 02188;BIX-02188

MAPK/ERK Signaling

MEK

MEK

Cancer

——

334949-59-6

412.48

C25H24N4O2

>98% (HPLC)

DMSO: ≥ 45 mg/mL

CN(C)CC1=CC(=CC=C1)N=C(C2=CC=CC=C2)C3=C(NC4=C3C=CC(=C4)C(=O)N)O

1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-, (3Z)-

(-20℃)

With Ice Pack

≥ 2 years