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Home - Products - Cytoskeleton/Cell Adhesion Molecules - Akt - BI-69A11

BI-69A11

CAS No. 1233322-09-2

BI-69A11( BI-69A11 | BI 69A11 | BI69A11 )

Catalog No. M10923 CAS No. 1233322-09-2

A potent, selective, ATP competitive AKT inhibitor with IC50 of 2.3 uM for Akt1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 87 Get Quote
25MG 170 Get Quote
50MG 245 Get Quote
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Biological Information

  • Product Name
    BI-69A11
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, ATP competitive AKT inhibitor with IC50 of 2.3 uM for Akt1.
  • Description
    A potent, selective, ATP competitive AKT inhibitor with IC50 of 2.3 uM for Akt1; displays no activity for other protein kinases including Abl1, p38α, JNK, and PI3K (IC50>100 uM); causes partial inhibition of AKT phosphorylation on S473 on melanoma cells at 3 uM; reduces AKT protein expression and AKT association with HSP-90; caused effective regression of melanoma tumor xenografts.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BI-69A11 | BI 69A11 | BI69A11
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Akt
  • Recptor
    Akt
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1233322-09-2
  • Formula Weight
    425.872
  • Molecular Formula
    C25H16ClN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1NC2=C(C=C(Cl)C=C2)C(C3=CC=CC=C3)=C1C(/C=C/C4=NC5=CC=CC=C5N4)=O
  • Chemical Name
    (E)-3-(3-(1H-benzo[d]imidazol-2-yl)acryloyl)-6-chloro-4-phenylquinolin-2(1H)-one(E)-3-(3-(1H-benzo[d]imidazol-2-yl)acryloyl)-6-chloro-4-phenylquinolin-2(1H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gaitonde S, et al. Pigment Cell Melanoma Res. 2009 Apr;22(2):187-95. 2. Feng Y, et al. Pigment Cell Melanoma Res. 2013 Jan;26(1):136-42. 3. Pal I, et al. Br J Cancer. 2014 Jul 8;111(1):101-11.
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