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BH3I-1

CAS No. 300817-68-9

BH3I-1 ( BHI1;BHI-1;BHI 1;BH 3I1 )

Catalog No. M13935 CAS No. 300817-68-9

A small-molecule Bcl-2 antagonist that inhibits the ineraction of Bak BH3 and Bcl-xL with Ki of 2.4 uM in FP binding assay.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BH3I-1
  • Note
    Research use only, not for human use.
  • Brief Description
    A small-molecule Bcl-2 antagonist that inhibits the ineraction of Bak BH3 and Bcl-xL with Ki of 2.4 uM in FP binding assay.
  • Description
    A small-molecule Bcl-2 antagonist that inhibits the ineraction of Bak BH3 and Bcl-xL with Ki of 2.4 uM in FP binding assay; specifically blocks the BH3-domain-mediated heterodimerization between Bcl-2 family members in vitro and in vivo and induces apoptosis; also potently inhibits p53/hDM2 with Kd of 5.3 uM.
  • Synonyms
    BHI1;BHI-1;BHI 1;BH 3I1
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bcl-xL-BH3;p53/MDM2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    300817-68-9
  • Formula Weight
    400.31
  • Molecular Formula
    C15H14BrNO3S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 3.9 mg/mL
  • SMILES
    O=C(O)C(C(C)C)N(C/1=O)C(SC1=C\C2=CC=C(Br)C=C2)=S
  • Chemical Name
    3-Thiazolidineacetic acid, 5-[(4-bromophenyl)methylene]-α-(1-methylethyl)-4-oxo-2-thioxo-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Degterev A, et al. Nat Cell Biol. 2001 Feb;3(2):173-82.
2. Wang L, et al. Bioorg Med Chem Lett. 2008 Jan 1;18(1):236-40.
3. Porter JR, et al. Chem Commun (Camb). 2010 Nov 14;46(42):8020-2.
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