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BH3I-1
CAS No. 300817-68-9
BH3I-1 ( BHI1;BHI-1;BHI 1;BH 3I1 )
Catalog No. M13935 CAS No. 300817-68-9
A small-molecule Bcl-2 antagonist that inhibits the ineraction of Bak BH3 and Bcl-xL with Ki of 2.4 uM in FP binding assay.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 35 | In Stock |
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| 5MG | 57 | In Stock |
|
| 10MG | 88 | In Stock |
|
| 25MG | 177 | In Stock |
|
| 50MG | 302 | In Stock |
|
| 100MG | 507 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBH3I-1
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NoteResearch use only, not for human use.
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Brief DescriptionA small-molecule Bcl-2 antagonist that inhibits the ineraction of Bak BH3 and Bcl-xL with Ki of 2.4 uM in FP binding assay.
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DescriptionA small-molecule Bcl-2 antagonist that inhibits the ineraction of Bak BH3 and Bcl-xL with Ki of 2.4 uM in FP binding assay; specifically blocks the BH3-domain-mediated heterodimerization between Bcl-2 family members in vitro and in vivo and induces apoptosis; also potently inhibits p53/hDM2 with Kd of 5.3 uM.
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SynonymsBHI1;BHI-1;BHI 1;BH 3I1
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBcl-xL-BH3;p53/MDM2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number300817-68-9
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Formula Weight400.31
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Molecular FormulaC15H14BrNO3S2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 3.9 mg/mL
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SMILESO=C(O)C(C(C)C)N(C/1=O)C(SC1=C\C2=CC=C(Br)C=C2)=S
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Chemical Name3-Thiazolidineacetic acid, 5-[(4-bromophenyl)methylene]-α-(1-methylethyl)-4-oxo-2-thioxo-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Degterev A, et al. Nat Cell Biol. 2001 Feb;3(2):173-82.
2. Wang L, et al. Bioorg Med Chem Lett. 2008 Jan 1;18(1):236-40.
3. Porter JR, et al. Chem Commun (Camb). 2010 Nov 14;46(42):8020-2.
2. Wang L, et al. Bioorg Med Chem Lett. 2008 Jan 1;18(1):236-40.
3. Porter JR, et al. Chem Commun (Camb). 2010 Nov 14;46(42):8020-2.
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