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BGP-15

CAS No. 66611-37-8

BGP-15( BGP 15 | BGP15 )

Catalog No. M15540 CAS No. 66611-37-8

A PARP inhibitor and an inducer of HSF-1/HSP72 (cotreatment with heat) in vtiro.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BGP-15
  • Note
    Research use only, not for human use.
  • Brief Description
    A PARP inhibitor and an inducer of HSF-1/HSP72 (cotreatment with heat) in vtiro.
  • Description
    A PARP inhibitor and an inducer of HSF-1/HSP72 (cotreatment with heat) in vtiro; has no effect on HSP90 levels, markedly increases the phosphorylation of HSF1 and expression of HSF1 and HSP72 in adipocytes and muscle cells; protects against obesity-induced insulin resistance and orally active; alleviates ventilation-induced diaphragm dysfunction associated with HSP72 induction and PARP-1 inhibition.Diabetes Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BGP 15 | BGP15
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    PARP
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    66611-37-8
  • Formula Weight
    351.272
  • Molecular Formula
    C14H24Cl2N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 11.33 mg/mL
  • SMILES
    C1CCN(CC1)CC(CON=C(C2=CN=CC=C2)N)O.Cl.Cl
  • Chemical Name
    3-Pyridinecarboximidamide, N-[2-hydroxy-3-(1-piperidinyl)propoxy]-, hydrochloride (1:2)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Salah H, et al. Sci Transl Med. 2016 Aug 3;8(350):350ra103. 2. Chung J, et al. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1739-44. 3. Racz I, et al. Biochem Pharmacol. 2002 Mar 15;63(6):1099-111. 4. Kardon T, et al. Anticancer Res. 2006 Mar-Apr;26(2A):1023-8.
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