BETd-246

CAS No. 2140289-17-2

BETd-246 ( BETd 246;BETd246 )

Catalog No. M13420 CAS No. 2140289-17-2

A potent, second-generation BET protein degrader that exhibits superior selectivity, potency and antitumor activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 485 Get Quote
10MG 710 Get Quote
25MG 1449 Get Quote
50MG 2196 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    BETd-246
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, second-generation BET protein degrader that exhibits superior selectivity, potency and antitumor activity.
  • Description
    A potent, second-generation BET protein degrader that exhibits superior selectivity, potency and antitumor activity; completely and selectively depletes BRD2, BRD3 and BRD4 in representative TNBC cell lines with 30-100 nM for 1 h or with 10-30 nM for 3 h incubation; displays strong growth inhibition and apoptosis induction activity in TNBC cell lines with IC50 <1 uM, induces a rapid and time-dependent downregulation of MCL1 protein; decreases BET proteins in xenograft breast tumors and suppress tumor growth in vivo without causing weight loss.
  • Synonyms
    BETd 246;BETd246
  • Pathway
    PROTACs
  • Target
    PROTAC
  • Recptor
    PROTAC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2140289-17-2
  • Formula Weight
    946.04
  • Molecular Formula
    C48H55N11O10
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 200 mg/mL 211.41 mM
  • SMILES
    CCN1C(=CC(=N1)C2CC2)NC3=NC(=NC4=C3C5=CC(=C(C=C5N4)C6=C(ON=C6C)C)OC)C(=O)NCCCOCCOCCOCCCNC7=CC=CC8=C7C(=O)N(C8=O)C9CCC(=O)NC9=O
  • Chemical Name
    4-((3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino)-7-(3,5-dimethylisoxazol-4-yl)-N-(3-(2-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propoxy)ethoxy)ethoxy)propyl)-6-methoxy-9H-pyrimido[4,5-b]indole-2-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bai L, et al. Cancer Res. 2017 May 1;77(9):2476-2487.
molnova catalog
related products
  • Boc-NH-PEG3-CH2COOH

    Boc-NH-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC

  • Azido-PEG10-alcohol

    Azido-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs

  • MS4077

    MS4077 is a novel PROTAC (degrader) of ALK, potently decreases cellular levels of oncogenic active ALK fusion proteins in a concentration- and time-dependent manner in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells (DC50=3 nM).