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BETP
CAS No. 1371569-69-5
BETP( —— )
Catalog No. M23523 CAS No. 1371569-69-5
BETP is an agonist of GLP-1 receptor (EC50s: 0.66 and 0.755 μM for human and rat GLP-1 receptor).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 51 | In Stock |
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| 5MG | 77 | In Stock |
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| 10MG | 128 | In Stock |
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| 25MG | 251 | In Stock |
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| 50MG | 448 | In Stock |
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| 100MG | 653 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBETP
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NoteResearch use only, not for human use.
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Brief DescriptionBETP is an agonist of GLP-1 receptor (EC50s: 0.66 and 0.755 μM for human and rat GLP-1 receptor).
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DescriptionBETP is an agonist of GLP-1 receptor (EC50s: 0.66 and 0.755 μM for human and rat GLP-1 receptor).
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In VitroBETP is a GLP-1 receptor agonist, with EC50s of 0.66 and 0.755 μM for human and rat GLP-1 receptor, respectively. BETP (Compound B) is inactive in cells expressing the GLP-2, GIP, PTH, or glucagon receptors. BETP (1-10 μM) enhances insulin secretion in normal and diabetic human islets. In addition, BETP in combination with GLP-1 shows additive effects on increasing GLP-1 receptor signaling. BETP increases the potency of oxyntomodulin by 10-fold (EC50 of 80 pM). GLP-1 does not change the potencies and efficacies of both oxyntomodulin and glucagon at the glucagon receptor. BETP (0-30 μM) increases the binding affinity of oxyntomodulin for the GLP-1 receptor.
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In VivoBETP has insulinotropic effect in SD rats. BETP (10 mg/kg, jugular vein cannula) exhibits insulin secretagogue activity in the intravenous glucose tolerance test (IVGTT) model. BETP (10 mg/kg, i.v.)-treated rats need 20% higher glucose infusion rates and demonstrates higher plasma insulin levels in SD rat hyperglycemic clamp model. BETP (5 mg/kg) enhances oxyntomodulin-stimulated insulin secretion.
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Synonyms——
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PathwayGPCR/G Protein
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TargetGlucagon Receptor
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RecptorGLP-1
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Research Area——
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Indication——
Chemical Information
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CAS Number1371569-69-5
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Formula Weight406.42
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Molecular FormulaC20H17F3N2O2S
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Purity>98% (HPLC)
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SolubilityDMSO:25 mg/mL (61.51 mM; Need ultrasonic);Water:Insoluble
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SMILESCCS(c1nc(-c2cc(OCc3ccccc3)ccc2)cc(C(F)(F)F)n1)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Sloop KW, et al. Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets. Diabetes. 2010 Dec;59(12):3099-107.
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