BCL6-IN-8 ( BCL6-i )

Catalog No. M13513 CAS No. 2204272-40-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BCL6-IN-8
Note

Research use only, not for human use.
Brief Description

BCL6-IN-8 (BCL6-i) is a potent, irreversible and cell-active BCL6 inhibitor with inact/KI value of 1.9 × 104 M-1 s-1, targets Cys53 located at the protein-protein interaction interface.
Description

BCL6-IN-8 (BCL6-i) is a potent, irreversible and cell-active BCL6 inhibitor with inact/KI value of 1.9 × 104 M-1 s-1, targets Cys53 located at the protein-protein interaction interface; shows intracellular PPI inhibitory activity between BCL6 and its corepressors, thus resulting in BCL6-dependent DLBCL cell growth inhibition; BCL6-i is a cell-active chemical probe with the most potent BCL6 inhibitory activity reported to date.
Synonyms

BCL6-i
Pathway

Angiogenesis
Target

Bcl-2
Recptor

Bcl-2
Research Area

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Indication

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CAS Number

2204272-40-0
Formula Weight

666.55
Molecular Formula

C30H37Cl2N5O8
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

(R)-N-(2-(7-((2-chloro-4-nitro-5-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)amino)-2-(4-(2-chloroacetamido)butyl)-3-oxo-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)ethyl)propionamide

1. Sameshima T, et al. Biochemistry. 2018 Feb 7. doi: 10.1021/acs.biochem.7b00732.

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