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BCH001

CAS No. 384859-58-9

BCH001 ( —— )

Catalog No. M22468 CAS No. 384859-58-9

BCH001 is a specific small-molecule inhibitor of PAPD5.BCH001, a specific PAPD5 inhibitor that restored telomerase activity and telomere length in DC patient induced pluripotent stem cells.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BCH001
  • Note
    Research use only, not for human use.
  • Brief Description
    BCH001 is a specific small-molecule inhibitor of PAPD5.BCH001, a specific PAPD5 inhibitor that restored telomerase activity and telomere length in DC patient induced pluripotent stem cells.?
  • Description
    BCH001 is a specific small-molecule inhibitor of PAPD5.BCH001, a specific PAPD5 inhibitor that restored telomerase activity and telomere length in DC patient induced pluripotent stem cells.?When human blood stem cells engineered to carry DC-causing PARN mutations were xenotransplanted into immunodeficient mice, oral treatment with a repurposed PAPD5 inhibitor, the dihydroquinolizinone RG7834, rescued TERC 3' end maturation and telomere length.?
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    PAPD5
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    384859-58-9
  • Formula Weight
    420.34
  • Molecular Formula
    C20H15F3N2O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:84 mg/mL (199.84 mM)
  • SMILES
    CCOC(=O)c1cnc2ccc(OC(F)(F)F)cc2c1Nc1ccccc1C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Nagpal N , Wang J , Zeng J , et al. Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells[J]. Cell stem cell, 2020.
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