BC-1471

CAS No. 896683-78-6

BC-1471 ( —— )

Catalog No. M22992 CAS No. 896683-78-6

BC-1471 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release after TLR agonism.A small-molecule inhibitor of STAMBP deubiquitinase activity, BC-1471, decreases NALP7 protein levels and suppresses IL-1β release after TLR agonism.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 147 Get Quote
10MG 237 Get Quote
25MG 507 Get Quote
50MG 731 Get Quote
100MG 1017 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    BC-1471
  • Note
    Research use only, not for human use.
  • Brief Description
    BC-1471 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release after TLR agonism.A small-molecule inhibitor of STAMBP deubiquitinase activity, BC-1471, decreases NALP7 protein levels and suppresses IL-1β release after TLR agonism.?
  • Description
    BC-1471 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release after TLR agonism.A small-molecule inhibitor of STAMBP deubiquitinase activity, BC-1471, decreases NALP7 protein levels and suppresses IL-1β release after TLR agonism.?These findings describe a unique pathway of inflammasome regulation with the identification of STAMBP as a potential therapeutic target to reduce pro-inflammatory stress.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    deubiquitinase STAM-binding protein (STAMBP)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    896683-78-6
  • Formula Weight
    504.6
  • Molecular Formula
    C27H28N4O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NCC1=CC=CO1)CSC(N2CCC3=CC=CC=C3)=NC4=C(C=C(N5CCOCC5)C=C4)C2=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Joseph S Bednash, Nathaniel Weathington, James Londino.Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity.Nat Commun. 2017 May 11;8:15203.
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