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BC-1471
CAS No. 896683-78-6
BC-1471 ( —— )
Catalog No. M22992 CAS No. 896683-78-6
BC-1471 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release after TLR agonism.A small-molecule inhibitor of STAMBP deubiquitinase activity, BC-1471, decreases NALP7 protein levels and suppresses IL-1β release after TLR agonism.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 147 | Get Quote |
|
| 10MG | 237 | Get Quote |
|
| 25MG | 507 | Get Quote |
|
| 50MG | 731 | Get Quote |
|
| 100MG | 1017 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBC-1471
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NoteResearch use only, not for human use.
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Brief DescriptionBC-1471 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release after TLR agonism.A small-molecule inhibitor of STAMBP deubiquitinase activity, BC-1471, decreases NALP7 protein levels and suppresses IL-1β release after TLR agonism.?
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DescriptionBC-1471 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release after TLR agonism.A small-molecule inhibitor of STAMBP deubiquitinase activity, BC-1471, decreases NALP7 protein levels and suppresses IL-1β release after TLR agonism.?These findings describe a unique pathway of inflammasome regulation with the identification of STAMBP as a potential therapeutic target to reduce pro-inflammatory stress.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptordeubiquitinase STAM-binding protein (STAMBP)
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Research Area——
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Indication——
Chemical Information
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CAS Number896683-78-6
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Formula Weight504.6
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Molecular FormulaC27H28N4O4S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NCC1=CC=CO1)CSC(N2CCC3=CC=CC=C3)=NC4=C(C=C(N5CCOCC5)C=C4)C2=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Joseph S Bednash, Nathaniel Weathington, James Londino.Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity.Nat Commun. 2017 May 11;8:15203.
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