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BC-1258

CAS No. 1507370-40-2

BC-1258( —— )

Catalog No. M23649 CAS No. 1507370-40-2

BC-1258 is a unique small molecule F-box/LRR-repeat protein 2 (FBXL2) activator.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BC-1258
  • Note
    Research use only, not for human use.
  • Brief Description
    BC-1258 is a unique small molecule F-box/LRR-repeat protein 2 (FBXL2) activator.
  • Description
    BC-1258 is a unique small molecule F-box/LRR-repeat protein 2 (FBXL2) activator.
  • In Vitro
    Cell Cycle Analysis Cell Line:MLE cells Concentration:2, 10, 50 μg/mL Incubation Time:16 hours Result:Significantly increased the cell population within the G2/M phase.Reduced the diploid cell population and increase the numbers of polyploidal cells in a dose-dependent manner.Western Blot Analysis Cell Line:U937, K562 and THP1 cells Concentration:2, 10 μg/mL Incubation Time:16 hours Result:Increased FBXL2 protein levels.Decreased FBXL2 substrates, including Aurora B, cyclin D2 and cyclin D3 levels.
  • In Vivo
    BC-1258 (30 μg/mL in the drinking water) significantly reduces tumor size and weight in athymic nude mice.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    FBXL2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1507370-40-2
  • Formula Weight
    406.57
  • Molecular Formula
    C22H22N4S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    C1=CC(=CC=C1CNCCNCC2=CC=C(C=C2)C3=NC=CS3)C4=NC=CS4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chen B B , Glasser J R , Coon T A , et al. Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis[J]. Cell Death & Disease, 2013, 4(8):e759.
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