BAY885( —— )

Catalog No. M24050 CAS No. 2307249-33-6

BAY885 is a new ERK5 inhibitor.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

BAY885
Note

Research use only, not for human use.
Brief Description

BAY885 is a new ERK5 inhibitor.
Description

BAY885 is a new ERK5 inhibitor.
In Vitro

The ERK5 probe 41 (BAY-885) showed potent ERK5 kinase and transcriptional inhibition in the SN12C-MEF2 reporter cell line (IC50 = 115 nM/IC90 = 691 nM) and had no effects on a reporter control cell line with constitutive luciferase expression (SN12C-CMV-luc, IC50 > 30 μM).
In Vivo

——
Synonyms

——
Pathway

MAPK/ERK Signaling
Target

ERK
Recptor

ERK5
Research Area

——
Indication

——

Chemical Information

CAS Number

2307249-33-6
Formula Weight

515.53
Molecular Formula

C25H28F3N7O2
Purity

>98% (HPLC)
Solubility

DMSO:16.67 mg/mL (32.34 mM; Need ultrasonic)
SMILES

CN1CCN(CC1)C2=CC3=C(C(=NC=N3)C4CCN(CC4)C(=O)C5=C(C=C(C=C5)OC(F)(F)F)N)N=C2
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Nguyen D, et al. Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5. J Med Chem. 2019 Jan 24;62(2):928-940.

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