BAY-545( —— )

Catalog No. M21950 CAS No. 1699717-32-2

BAY-545 is an antagonist of A2B adenosine receptor(IC50 : 59 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

BAY-545
Note

Research use only, not for human use.
Brief Description

BAY-545 is an antagonist of A2B adenosine receptor(IC50 : 59 nM).
Description

BAY-545 is an antagonist of A2B adenosine receptor(IC50 : 59 nM).
In Vitro

BAY-545 is selective at A2B adenosine receptor over A1, A2A, and A3 adenosine receptor, with IC50s of 1300 nM (Human A1 adenosine receptor), 820 nM (Human A2A adenosine receptor), 470 nM (Mouse A2A adenosine receptor) and 750 nM (Rat A2A adenosine receptor).
In Vivo

——
Synonyms

——
Pathway

Apoptosis
Target

Adenosine Receptor
Recptor

A2B?adenosine receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

1699717-32-2
Formula Weight

433.45
Molecular Formula

C18H22F3N3O4S
Purity

>98% (HPLC)
Solubility

DMSO:145 mg/ml(334.53 mM)
SMILES

CCn1c(=O)n(CCC(F)(F)F)c2sc(C(=O)N3CCC(O)CC3)c(C)c2c1=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.H?rter M, et al. Novel non-xanthine antagonist of the A2B adenosine receptor: From HTS hit to lead structure. Eur J Med Chem. 2019 Feb 1;163:763-778.

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