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Home - Products - Metabolic Enzyme/Protease - PPAR - BAY-4931

BAY-4931

CAS No. 423150-91-8

BAY-4931( —— )

Catalog No. M36091 CAS No. 423150-91-8

BAY-4931 is a powerful, covalent, and selective inverse-agonist of PPARγ, exhibiting an IC50 value of 0.17 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 76 Get Quote
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Biological Information

  • Product Name
    BAY-4931
  • Note
    Research use only, not for human use.
  • Brief Description
    BAY-4931 is a powerful, covalent, and selective inverse-agonist of PPARγ, exhibiting an IC50 value of 0.17 nM.
  • Description
    BAY-4931 is a potent, covalent and selective PPARγ inverse-agonist with an IC50 of 0.17 nM.
  • In Vitro
    BAY-4931 (0-10 μM; 7 days) inhibits UM-UC-9 proliferation with an IC50 of 3.4 nM.BAY-4931 only inhibits CYP2C8 in CYP inhibition test.Cell Proliferation Assay Cell Line:UM-UC-9 cells Concentration:0-10 μM Incubation Time:7 days Result:Inhibited proliferation with an IC50 of 3.4 nM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    PPAR
  • Recptor
    PPAR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    423150-91-8
  • Formula Weight
    421.83
  • Molecular Formula
    C22H16ClN3O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (296.33 mM; Ultrasonic (<70°C)
  • SMILES
    N(C(=O)C1=CC(N(=O)=O)=CC=C1Cl)C=2C=C3C(OC(=N3)C4=CC=C(CC)C=C4)=CC2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Orsi DL, et al. Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069. J Med Chem. 2022 Nov 10;65(21):14843-14863.?
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