BAY-069

CAS No. 2639638-66-5

BAY-069( —— )

Catalog No. M36084 CAS No. 2639638-66-5

BAY-069 is an inhibitor. BAY-069 inhibited branched-chain amino acid transaminase 1 (BCAT1) at IC50:31 nM and branched-chain amino acid transaminase 2 (BCAT2) at IC50:153 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 231 Get Quote
5MG 359 Get Quote
10MG 535 Get Quote
25MG 819 Get Quote
50MG 1132 Get Quote
100MG 1503 Get Quote
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Biological Information

  • Product Name
    BAY-069
  • Note
    Research use only, not for human use.
  • Brief Description
    BAY-069 is an inhibitor. BAY-069 inhibited branched-chain amino acid transaminase 1 (BCAT1) at IC50:31 nM and branched-chain amino acid transaminase 2 (BCAT2) at IC50:153 nM.
  • Description
    BAY-069 is a potent branched-chain amino acid transaminases 1 (BCAT1) and BCAT2 inhibitor with IC50 values of 31 nM and 153 nM, respectively. BAY-069 also can be used as a chemical probe. BAY-069 can be used tor research anticancer.
  • In Vitro
    BAY-069 (compound 36a) (70 nM-50 μM; 72 h) inhibits cell proliferation of U-87 and MDA-MB-231.Cell Proliferation Assay Cell Line:U-87 and MDA-MB-231 Concentration:70 nM-50 μM Incubation Time:72 h Result:Inhibited cell proliferation of U-87 and MDA-MB-231 with IC50s of 358 nM and 874 nM, respectively.
  • In Vivo
    BAY-069 exhibits high metabolic stability after incubation with human liver microsomes (CLblood = 0.11 L/h/kg) and moderate metabolic stability after incubation with rat hepatocytes (CLblood = 1.8 L/h/kg); shows high permeability through Caco-2 cell monolayers with no hint of efflux.BAY-069 (0.3 mg/kg for i.v.; 0.6 mg/kg for p.o.; single dosage) exhibits a favorable pharmacokinetic profile after i.v. dosing with low blood clearance (CLblood), moderate volume of distribution at steady state (Vss), and intermediate terminal half-life (t1/2).Animal Model:Male Wistar rats Dosage:0.3 mg/kg for i.v.; 0.6 mg/kg for p.o.Administration:i.v. or p.o.; single dosage Result:Pharmacokinetic Parameters of BAY-069 in male Wistar rats.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Reactive Oxygen Species
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2639638-66-5
  • Formula Weight
    446.81
  • Molecular Formula
    C22H14ClF3N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 200 mg/mL (447.62 mM; Ultrasonic )
  • SMILES
    O=C1N(C=2C3=C(C(Cl)=C(OC4=C(C)C=CC=C4)C2)C=CC=C3)C(=O)NC(C(F)(F)F)=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Günther J, et al. BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe. J Med Chem. 2022 Oct 19.?
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