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Azeloprazole

CAS No. 955095-45-1

Azeloprazole( E-3710 | Z-215 )

Catalog No. M16817 CAS No. 955095-45-1

A novel potent proton pump inhibitor that irreversibly inhibits H+,K+-ATPase activity with IC50 of 0.28 uM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Azeloprazole
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel potent proton pump inhibitor that irreversibly inhibits H+,K+-ATPase activity with IC50 of 0.28 uM.
  • Description
    A novel potent proton pump inhibitor that irreversibly inhibits H+,K+-ATPase activity with IC50 of 0.28 uM; inhibits histamine-stimulated gastric acid secretion with ED50 of 0.18-0.2 mg/kg in gastric fistula model in dogs, displays 2.3-fold more potency over Esomeprazole.Other Indication Phase 1 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    E-3710 | Z-215
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Proton Pump
  • Recptor
    Proton Pump
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    955095-45-1
  • Formula Weight
    429.535
  • Molecular Formula
    C22H27N3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC1=CN=C(C(=C1OCC2COC(OC2)(C)C)C)CS(=O)C3=NC4=CC=CC=C4N3
  • Chemical Name
    (R)-2-(((4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kodama K, et al. J Pharmacol Exp Ther. 2010 Aug;334(2):395-401. 2. Toda R, et al. J Clin Pharmacol. 2017 Nov 28. doi: 10.1002/jcph.1038. 3. Toda R, et al. Xenobiotica. 2017 Nov 2:1-15. doi: 10.1080/00498254.2017.1390625.
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