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Azaserine
CAS No. 115-02-6
Azaserine( CI-337 | O-Diazoacetyl-L-serine | P-165 )
Catalog No. M29606 CAS No. 115-02-6
Azaserine is a tumor-inhibiting antibiotic isolated from a species of Streptomyces and functions as an inhibitor of glutamine amidotransferase.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameAzaserine
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NoteResearch use only, not for human use.
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Brief DescriptionAzaserine is a tumor-inhibiting antibiotic isolated from a species of Streptomyces and functions as an inhibitor of glutamine amidotransferase.
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DescriptionAzaserine is a tumor-inhibiting antibiotic isolated from a species of Streptomyces and functions as an inhibitor of glutamine amidotransferase.(In Vitro):Azaserine inhibits the hexosamine biosynthetic pathway, which shunts excessive intracellular glucose into the biosynthesis of UDP-N-acetylglucosamine and the formation of O-linked glycoproteins . Azaserine (25 μM) inhibits the glutamine-dependent amidotransferases involved in nucleotide biosynthesis, phosphoribosylformylglycinamidine synthetase, and glucosamine-6-phosphate isomerase.
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In VitroAzaserine (100 μg/mL; 6 h) causes some specific types of morphological changes of the sensitive organisms such as the characteristic elongation of Candida albicans cells.Azaserine (0-10 μM) inhibits the growth of E. coli strains with MIC values of 12.11, 51.9, 69.2 and 69.2 μg/mL for UTH 4, UTH 7036, UTH 7048 and UTH 7049.
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In VivoAzaserine (5 mg/kg; i.p. once or twice a week for 6 months) induces tumor in rats. Animal Model:Wistar rats Dosage:5 mg/kg Administration:Intraperitoneal injection; 5 mg/kg once or twice a week for 6 month Result:After 1 year most pancreases from treated rats were diffusely abnormal and contained many hyperplastic nodules and adenomas and more than rats one-quarter showed pancreatic adenocarcinoma.
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SynonymsCI-337 | O-Diazoacetyl-L-serine | P-165
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number115-02-6
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Formula Weight173.128
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Molecular FormulaC5H7N3O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 50 mg/mL (288.80 mM)
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SMILESN[C@@H](COC(=O)C=[N+]=[N-])C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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