Aurantio-obtusin

Research use only, not for human use.

Aurantio-obtusin is a promising osteoanabolic compound of natural origin with potential therapeutic applications in the prevention of osteoporosis and other metabolic bone diseases.

Biotransformation of glucoAurantio-obtusin towards Aurantio-obtusin increased the toxicity of irinotecan through increased inhibition of SN-38 glucuronidation. Aurantio-obtusin, stimulated chemotactic migration of MC3T3-E1 osteoblast cells in a concentration-dependent manner. Besides migration, the compound stimulated osteoblast differentiation and mineralization. Aurantio-obtusin is a promising osteoanabolic compound of natural origin with potential therapeutic applications in the prevention of osteoporosis and other metabolic bone diseases.

——

Animal Model:C57BL/6J mice model Dosage:5 mg/kg, 10 mg/kg, 15 mg/kg Administration:Oral gavage (p.o.), feeding with HFSW diet for 4 weeks then giving different dose of Aurantio-obtusin for another 4 weeks. Result:Decreased the levels of TG and TC in liver and TG, ALT and AST in serum induced by HSFW.Reduced the number and size of fat droplets in liver cells.Significantly increased AMPK phosphorylation in HFSW-induced mice.

——

Others

Other Targets

Others

Others-Field

——

67979-25-3

330.29

C17H14O7

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (75.69 mM)

CC1=C(C(=C2C(=C1)C(=O)C3=CC(=C(C(=C3C2=O)O)OC)O)OC)O

——

(-20℃)

With Ice Pack

≥ 2 years