Cart
sales@molnova.com
Home - Products - Angiogenesis - JAK - Atiprimod

Atiprimod

CAS No. 123018-47-3

Atiprimod( SKF 106615 | Azaspirane )

Catalog No. M10907 CAS No. 123018-47-3

Atiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 1233 Get Quote
50MG 2502 Get Quote
100MG 3330 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Atiprimod
  • Note
    Research use only, not for human use.
  • Brief Description
    Atiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways.
  • Description
    Atiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways; efficaciously inhibits the proliferation of FDCP-EpoR JAK2 (V617F) (IC50=0.42 uM) and SET-2 cells (IC50= 0.53 uM); blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells (MM.1S, U266, and RPMI8226 MM cell lines IC50=0.5-1.25 uM), significantly inhibits production of IL-6 and inflammation in rat arthritis and autoimmune animal models.Brain Cancer Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SKF 106615 | Azaspirane
  • Pathway
    Angiogenesis
  • Target
    JAK
  • Recptor
    JAK
  • Research Area
    Cancer
  • Indication
    Brain Cancer

Chemical Information

  • CAS Number
    123018-47-3
  • Formula Weight
    336.608
  • Molecular Formula
    C22H44N2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCN(CC)CCCN1CCC2(CCC(CCC)(CCC)CC2)C1
  • Chemical Name
    N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Quintás-Cardama A, et al. Invest New Drugs. 2011 Oct;29(5):818-26. 2. Neri P, et al. Leukemia. 2007 Dec;21(12):2519-26. 3. Hamasaki M, et al. Blood. 2005 Jun 1;105(11):4470-6. 4. Choudhari SR, et al. Mol Cancer Ther. 2007 Jan;6(1):112-21.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • LY2784544

    LY2784544 (Gandotinib) is a potent, selective and ATP-competitive inhibitor of JAK2V617F.

  • Peficitinib

    Peficitinib (ASP-015K, JNJ-54781532) is a potent JAK inhibitor with IC50s of 3.9 and 0.7 nM for JAK1 and JAK3 respectively; inhibits IL-2-dependent T cell proliferation in vitro and STAT5 phosphorylation in vitro and ex vivo.

  • Ruxolitinib

    A potent, selective, orally active JAK1/JAK2 inhibitor with IC50 of 3.3/2.8 nM, respectively.

Sign In Join Free