Astragaloside ( —— )

Catalog No. M19309 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Astragaloside
Note

Research use only, not for human use.
Brief Description

Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
Description

Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 μM; LC50 = 865 μM).It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts.
Synonyms

——
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

ERK1; ERK2; JNK; MMP-2; MMP-9
Research Area

——
Indication

——

CAS Number

--
Formula Weight

784.97
Molecular Formula

C41H68O14
Purity

95%
Solubility

——
SMILES

C[C@]12CC[C@@]34C[C@@]35CC[C@@H](C([C@@H]5[C@H](C[C@H]4[C@@]1(C[C@@H]([C@@H]2[C@]6(CC[C@H](O6)C(C)(C)O)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)(C)C)O[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O
Chemical Name

——

1. Li M, et al. Neurosci Lett. 2016 Dec 20. pii: S0304-3940(16)30994-6

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