Astragaloside
CAS No.
Astragaloside ( —— )
Catalog No. M19309 CAS No.
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
Purity : 95%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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100MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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Biological Information
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Product NameAstragaloside
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NoteResearch use only, not for human use.
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Brief DescriptionAstragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
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DescriptionAstragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 μM; LC50 = 865 μM).It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts.
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Synonyms——
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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RecptorERK1; ERK2; JNK; MMP-2; MMP-9
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Research Area——
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Indication——
Chemical Information
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CAS Number--
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Formula Weight784.97
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Molecular FormulaC41H68O14
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Purity95%
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Solubility——
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SMILESC[C@]12CC[C@@]34C[C@@]35CC[C@@H](C([C@@H]5[C@H](C[C@H]4[C@@]1(C[C@@H]([C@@H]2[C@]6(CC[C@H](O6)C(C)(C)O)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)(C)C)O[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Li M, et al. Neurosci Lett. 2016 Dec 20. pii: S0304-3940(16)30994-6
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