Asimadoline ( Asimadoline )

Catalog No. M18069 CAS No. 153205-46-0

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Product Name

Asimadoline
Note

Research use only, not for human use.
Brief Description

Asimadoline is a proprietary small molecule therapeutic, originally developed to treat peripheral pain such as arthritis.
Description

Asimadoline is a proprietary small molecule therapeutic, originally discovered by Merck KGaA of Darmstadt, Germany. Asimadoline was originally developed to treat peripheral pain such as arthritis. Asimadoline is an orally administered agent that acts as a kappa opioid receptor agonist. It has shown encouraging clinical efficacy for the treatment of IBS in a barostat study in IBS patients and has the potential for treating other gastrointestinal diseases.
Synonyms

Asimadoline
Pathway

Cell Cycle/DNA Damage
Target

DNA/RNA Synthesis
Recptor

κ opioid
Research Area

——
Indication

——

CAS Number

153205-46-0
Formula Weight

414.54
Molecular Formula

C27H30N2O2
Purity

98%
Solubility

DMSO : ≥ 103.3 mg/mL; 249.19 mM
SMILES

CN([C@H](CN1CC[C@@H](C1)O)C2=CC=CC=C2)C(=O)C(C3=CC=CC=C3)C4=CC=CC=C4
Chemical Name

Benzeneacetamide, N-((1S)-2-((3S)-3-hydroxy-1-pyrrolidinyl)-1-phenylethyl)-N-methyl-alpha-phenyl-

1.Camilleri M, et al. Asimadoline, a κ-Opioid Agonist, and Visceral Sensation. Neurogastroenterol Motil. 2008 Sep; 20(9): 971–979.

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