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Aprepitant

CAS No. 170729-80-3

Aprepitant ( MK-0869;MK-869;L-754030 )

Catalog No. M12607 CAS No. 170729-80-3

A potent, orally active, long-acting human NK-1 receptor (substance P receptor) antagonist with IC50 of 0.09 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Aprepitant
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, orally active, long-acting human NK-1 receptor (substance P receptor) antagonist with IC50 of 0.09 nM.
  • Description
    A potent, orally active, long-acting human NK-1 receptor (substance P receptor) antagonist with IC50 of 0.09 nM; blocks NK-1 agonist-induced foot tapping response in gerbils and shows antiemetic actions in the ferret against cisplatin challenge; has the potentiation for the treatment of peripheral pain, migraine, chemotherapy-induced emesis, and various psychiatric disorders.Chemotherapeutic Agents Approved
  • Synonyms
    MK-0869;MK-869;L-754030
  • Pathway
    GPCR/G Protein
  • Target
    Neurokinin Receptor
  • Recptor
    NK1
  • Research Area
    Cancer
  • Indication
    Chemotherapeutic

Chemical Information

  • CAS Number
    170729-80-3
  • Formula Weight
    534.43
  • Molecular Formula
    C23H21F7N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C1NNC(CN2[C@@H](C3=CC=C(F)C=C3)[C@@H](O[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C)OCC2)=N1
  • Chemical Name
    3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kramer MS, et al. Science. 1998 Sep 11;281(5383):1640-5.
2. Hale JJ, et al. J Med Chem. 1998 Nov 5;41(23):4607-14.
3. Tattersall FD, et al. Neuropharmacology. 2000 Feb 14;39(4):652-63.
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