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Aprepitant
CAS No. 170729-80-3
Aprepitant ( MK-0869;MK-869;L-754030 )
Catalog No. M12607 CAS No. 170729-80-3
A potent, orally active, long-acting human NK-1 receptor (substance P receptor) antagonist with IC50 of 0.09 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 43 | In Stock |
|
| 10MG | 52 | In Stock |
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| 50MG | 73 | In Stock |
|
| 100MG | 88 | In Stock |
|
| 200MG | 105 | In Stock |
|
| 500MG | 133 | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAprepitant
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, orally active, long-acting human NK-1 receptor (substance P receptor) antagonist with IC50 of 0.09 nM.
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DescriptionA potent, orally active, long-acting human NK-1 receptor (substance P receptor) antagonist with IC50 of 0.09 nM; blocks NK-1 agonist-induced foot tapping response in gerbils and shows antiemetic actions in the ferret against cisplatin challenge; has the potentiation for the treatment of peripheral pain, migraine, chemotherapy-induced emesis, and various psychiatric disorders.Chemotherapeutic Agents Approved
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SynonymsMK-0869;MK-869;L-754030
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PathwayGPCR/G Protein
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TargetNeurokinin Receptor
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RecptorNK1
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Research AreaCancer
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IndicationChemotherapeutic
Chemical Information
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CAS Number170729-80-3
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Formula Weight534.43
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Molecular FormulaC23H21F7N4O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C1NNC(CN2[C@@H](C3=CC=C(F)C=C3)[C@@H](O[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C)OCC2)=N1
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Chemical Name3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kramer MS, et al. Science. 1998 Sep 11;281(5383):1640-5.
2. Hale JJ, et al. J Med Chem. 1998 Nov 5;41(23):4607-14.
3. Tattersall FD, et al. Neuropharmacology. 2000 Feb 14;39(4):652-63.
2. Hale JJ, et al. J Med Chem. 1998 Nov 5;41(23):4607-14.
3. Tattersall FD, et al. Neuropharmacology. 2000 Feb 14;39(4):652-63.
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