Apoptozole

Research use only, not for human use.

Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce apoptosis.

Apoptozole, also known as Apoptosis Activator VII, is a selective inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity. Apoptozole enhances immune responses to administered antigens. Treatment of mice with Apoptozole elicits production of antibodies with a high IgG2c/IgG1 ratio and stimulates the release of Th1 and Th2-type cytokines, suggesting that Apoptozole activates the Th1 and Th2 immune responses. The ATPase activities of Hsp70 and Hsc70 are known to be responsible for regulation of various biological processes.

Apoptozole; Apoptosis Activator VII

Others

Other Targets

HSC70; HSP70

Cancer

——

1054543-47-3

625.56

C33H25F6N3O3

98%

DMSO : ≥ 31 mg/mL; 49.56 mM

COC1=CC=C(C=C1)C2=C(N(C(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)CC4=CC=C(C=C4)C(=O)N)C5=CC=C(C=C5)OC

4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl)methyl)benzamide

(-20℃)

With Ice Pack

≥ 2 years