Aplidine

CAS No. 137219-37-5

Aplidine ( Plitidepsin )

Catalog No. M28854 CAS No. 137219-37-5

Aplidine possesses antiviral activity against SARS-CoV-2(IC90 = 0.88 nM). Aplidine is a potent anti-cancer agent by targeting eukaryotic translation elongation factor 1 Alpha 2(EEF1A2, Kd = 80?nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 655 Get Quote
10MG 888 Get Quote
25MG 1377 Get Quote
50MG 1782 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Aplidine
  • Note
    Research use only, not for human use.
  • Brief Description
    Aplidine possesses antiviral activity against SARS-CoV-2(IC90 = 0.88 nM). Aplidine is a potent anti-cancer agent by targeting eukaryotic translation elongation factor 1 Alpha 2(EEF1A2, Kd = 80?nM).
  • Description
    Aplidine possesses antiviral activity against SARS-CoV-2(IC90 = 0.88 nM). Aplidine is a potent anti-cancer agent by targeting eukaryotic translation elongation factor 1 Alpha 2(EEF1A2, Kd = 80?nM).(In Vitro):In hACE2-293T cells, Aplidine exhibits anti–SARS-CoV-2 activity with an IC90 of 0.88 nM. In an established model of human pneumocyte-like cells, Aplidine inhibits SARS-CoV-2 replication with an IC90 of 3.14 nM and a selectivity index of 40.4. Aplidine (20 nM; 1 h) induces a dose-dependent decrease in VEGF secretion in MOLT-4 cells. Aplidine (20 nM; 1 h) does not result in significant inhibition of VEGF-R1 mRNA in normal endothelial cells, which do express VEGFR-1 but do not secrete VEGF.(In Vivo):In BALB/c mice expressing human ACE2, Aplidine significantly reduced SARS-CoV-2 infection. 0.3 mg/kg Aplidine group results in a reduction of nearly 2 log units in SARS-CoV-2 viral titers in the lungs, and the 1 mg/kg group leads to a reduction of 1.5 log units.
  • Synonyms
    Plitidepsin
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    EP1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    137219-37-5
  • Formula Weight
    1110.3
  • Molecular Formula
    C57H87N7O15
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC[C@@H]([C@@H]1[C@@H](O)CC(O[C@@H](C(C)C)C([C@H](C)C(N[C@@H](CC(C)C)C(N2CCC[C@H]2C(N(C)[C@@H](CC3=CC=C(OC)C=C3)C(O[C@H](C)[C@H](NC([C@H](N(C([C@@H]4CCCN4C(C(C)=O)=O)=O)C)CC(C)C)=O)C(N1)=O)=O)=O)=O)=O)=O)=O)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.McKeown SC, et al. Identification of novel pyrazole acid antagonists for the EP1 receptor. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4767-7Epub 2006 Jul 14.
molnova catalog
related products
  • Malotilate

    Malotilate, diisopropyl 1,3-dithiol-2-ylidenemalonate, is a drug used for the treatment of liver cirrhosis.

  • BETA-CFT sulfate

    BETA-CFT sulfate is a chemical compound.

  • Dihydromollugin

    Dihydromollugin is a naphthol ester found in Rubia cordifolia that may have anti-tumour, virus-inhibiting and other activities.