Apararenone( MT-3995 | MT3995 )

Catalog No. M16779 CAS No. 945966-46-1

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Product Name

Apararenone
Note

Research use only, not for human use.
Brief Description

Apararenone (MT-3995) is a novel potent, selective non-steroidal mineralocorticoid receptor antagonist for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.
Description

Apararenone (MT-3995) is a novel potent, selective non-steroidal mineralocorticoid receptor antagonist for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.Steatohepatitis Phase 2 Clinical.
In Vitro

——
In Vivo

Recently, a phase II clinical trial has been initiated among patients with non-alcoholic steatohepatitis (NASH) in Japan.
Synonyms

MT-3995 | MT3995
Pathway

Nuclear Receptor/Transcription Factor
Target

MLR
Recptor

MLR
Research Area

Other Indications
Indication

Steatohepatitis

CAS Number

945966-46-1
Formula Weight

364.391
Molecular Formula

C17H17FN2O4S
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 125 mg/mL 343.04 mM
SMILES

CS(=O)(NC1=CC=C2N(C3=CC=C(F)C=C3)C(C(C)(C)OC2=C1)=O)=O
Chemical Name

N-(4-(4-fluorophenyl)-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)methanesulfonamide

1. Kolkhof P, et al. Curr Opin Nephrol Hypertens. 2015 Sep;24(5):417-24. 2. Kolkhof P, et al. J Endocrinol. 2017 Jul;234(1):T125-T140.

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