Apararenone

CAS No. 945966-46-1

Apararenone( MT-3995 | MT3995 )

Catalog No. M16779 CAS No. 945966-46-1

Apararenone (MT-3995) is a novel potent, selective non-steroidal mineralocorticoid receptor antagonist for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 56 Get Quote
10MG 76 Get Quote
25MG 118 Get Quote
50MG 170 Get Quote
100MG 248 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Apararenone
  • Note
    Research use only, not for human use.
  • Brief Description
    Apararenone (MT-3995) is a novel potent, selective non-steroidal mineralocorticoid receptor antagonist for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.
  • Description
    Apararenone (MT-3995) is a novel potent, selective non-steroidal mineralocorticoid receptor antagonist for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.Steatohepatitis Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    Recently, a phase II clinical trial has been initiated among patients with non-alcoholic steatohepatitis (NASH) in Japan.
  • Synonyms
    MT-3995 | MT3995
  • Pathway
    Nuclear Receptor/Transcription Factor
  • Target
    MLR
  • Recptor
    MLR
  • Research Area
    Other Indications
  • Indication
    Steatohepatitis

Chemical Information

  • CAS Number
    945966-46-1
  • Formula Weight
    364.391
  • Molecular Formula
    C17H17FN2O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 125 mg/mL 343.04 mM
  • SMILES
    CS(=O)(NC1=CC=C2N(C3=CC=C(F)C=C3)C(C(C)(C)OC2=C1)=O)=O
  • Chemical Name
    N-(4-(4-fluorophenyl)-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)methanesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kolkhof P, et al. Curr Opin Nephrol Hypertens. 2015 Sep;24(5):417-24. 2. Kolkhof P, et al. J Endocrinol. 2017 Jul;234(1):T125-T140.
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