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Apararenone

CAS No. 945966-46-1

Apararenone( MT-3995 | MT3995 )

Catalog No. M16779 CAS No. 945966-46-1

Apararenone (MT-3995) is a novel potent, selective non-steroidal mineralocorticoid receptor antagonist for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Apararenone
  • Note
    Research use only, not for human use.
  • Brief Description
    Apararenone (MT-3995) is a novel potent, selective non-steroidal mineralocorticoid receptor antagonist for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.
  • Description
    Apararenone (MT-3995) is a novel potent, selective non-steroidal mineralocorticoid receptor antagonist for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.Steatohepatitis Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    Recently, a phase II clinical trial has been initiated among patients with non-alcoholic steatohepatitis (NASH) in Japan.
  • Synonyms
    MT-3995 | MT3995
  • Pathway
    Nuclear Receptor/Transcription Factor
  • Target
    MLR
  • Recptor
    MLR
  • Research Area
    Other Indications
  • Indication
    Steatohepatitis

Chemical Information

  • CAS Number
    945966-46-1
  • Formula Weight
    364.391
  • Molecular Formula
    C17H17FN2O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 125 mg/mL 343.04 mM
  • SMILES
    CS(=O)(NC1=CC=C2N(C3=CC=C(F)C=C3)C(C(C)(C)OC2=C1)=O)=O
  • Chemical Name
    N-(4-(4-fluorophenyl)-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)methanesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kolkhof P, et al. Curr Opin Nephrol Hypertens. 2015 Sep;24(5):417-24. 2. Kolkhof P, et al. J Endocrinol. 2017 Jul;234(1):T125-T140.
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