Anlotinib ( AL-3818 )

Catalog No. M10263 CAS No. 1058156-90-3

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Product Name

Anlotinib
Note

Research use only, not for human use.
Brief Description

Anlotinib (AL-3818) is a novel multi-target tyrosine kinase that primarily inhibit VEGFR2/3, FGFR1-4, PDGFR α/β, c-Kit, and Ret.
Description

Anlotinib (AL-3818) is a novel multi-target tyrosine kinase that primarily inhibit VEGFR2/3, FGFR1-4, PDGFR α/β, c-Kit, and Ret; shows antitumor activity against tumor cells carrying mutations in PDGFR α, c-Kit, Met, and epidermal growth factor receptor (EGFR).Colon Cancer Phase 2 Clinical
Synonyms

AL-3818
Pathway

Angiogenesis
Target

EGFR
Recptor

EGFR
Research Area

Cancer
Indication

Colon Cancer

CAS Number

1058156-90-3
Formula Weight

407.44
Molecular Formula

C23H22FN3O3
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 44 mg/mL
SMILES

CC1=CC2=C(N1)C=CC(=C2F)OC3=C4C=C(C(=CC4=NC=C3)OCC5(CC5)N)OC
Chemical Name

Cyclopropanamine, 1-[[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-quinolinyl]oxy]methyl]-

1. Sun Y, et al. J Hematol Oncol. 2016 Oct 4;9(1):105.

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