
Aniracetam
CAS No. 72432-10-1
Aniracetam( Memodrin | Ro 13-5057 | Sarpul )
Catalog No. M15773 CAS No. 72432-10-1
Aniracetam(Ro 13-5057) is a nootropics and neuroprotective drug, which is selectively modulates the AMPA receptor and nAChR.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
500MG | 37 | In Stock |
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1G | 66 | In Stock |
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Biological Information
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Product NameAniracetam
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NoteResearch use only, not for human use.
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Brief DescriptionAniracetam(Ro 13-5057) is a nootropics and neuroprotective drug, which is selectively modulates the AMPA receptor and nAChR.
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DescriptionAniracetam(Ro 13-5057) is a nootropics and neuroprotective drug, which is selectively modulates the AMPA receptor and nAChR.(In Vitro):Aniracetam concentration-dependently counteracts glutsmate-, kainate-, or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced cell death and greatly facilitated neuroprotective response achieved by different concentrations of both quisqualate and trans-1-aminocyclopentane-1, 3-dicarboxylate in primary cultures of cerebellar granule cells.Aniracetam potentiates the mGluR-coupled stimulation of phospholipase C in primary cultures of cerebellar granule cells.(In Vivo):Aniracetam (1 mM; 30-75 min) potentiates the iQA receptors and produces remarkable facilitation of the native synaptic transmission in rats.Aniracetam (10-100 mg/kg; p.o.; single dosage) prevents the CO2-induced impairment of acquisition in rats.Aniracetam (30-300 mg/kg; p.o.; single dosage) increases the percentage of rats showing passive avoidance.
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In VitroAniracetam concentration-dependently counteracts glutsmate-, kainate-, or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced cell death and greatly facilitated neuroprotective response achieved by different concentrations of both quisqualate and trans-1-aminocyclopentane-1, 3-dicarboxylate in primary cultures of cerebellar granule cells.Aniracetam potentiates the mGluR-coupled stimulation of phospholipase C in primary cultures of cerebellar granule cells.
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In VivoAniracetam (1 mM; 30-75 min) potentiates the iQA receptors and produces remarkable facilitation of the native synaptic transmission in rats.Aniracetam (10-100 mg/kg; p.o.; single dosage) prevents the CO2-induced impairment of acquisition in rats.Aniracetam (30-300 mg/kg; p.o.; single dosage) increases the percentage of rats showing passive avoidance. Animal Model:Pyramidal neurons from male Wistar rats Dosage:1 mM Administration:30-75 min Result:Potentiated the iQA receptors existing in the brain and produced remarkable facilitation of the native synaptic transmission.Animal Model:Male rats (100-120 g; hypercapnia induced by pure CO2)Dosage:10, 30, 50 and 100 mg/kg Administration:p.o.; single dosage (60 min before hypercapnia)Result:Significantly prevented the CO2-induced impairment of acquisition at 30 and 50 mg/kg.Animal Model:Male rats and male mice (100-120 g and 21-25 g; 0.5 mg/kg Scopolamine-induced transient disruption of the memory of a passive avoidance procedure)Dosage:30, 50, 100 and 300 mg/kg,Administration:p.o.; single dosage Result:Significantly increased the percentage of rats showing passive avoidance 2 h after Scopolamine (HY-N0296) at 50 and 100 mg/kg.
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SynonymsMemodrin | Ro 13-5057 | Sarpul
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT| Dopamine| AMPA| GluR
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number72432-10-1
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Formula Weight219.24
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Molecular FormulaC12H13NO3
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Purity>98% (HPLC)
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SolubilityEthanol: 18 mg/mL (82.1 mM); DMSO: 44 mg/mL (200.69 mM)
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SMILESO=C1N(C(C2=CC=C(OC)C=C2)=O)CCC1
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Chemical Name1-(4-methoxybenzoyl)pyrrolidin-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Nakamura K, Kurasawa M. Eur J Pharmacol. 2001 May 18;420(1):33-43.
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