Anemonin

Research use only, not for human use.

Anemonin is a natural product from Pulsatilla chinensis Regel.

Anemonin is a natural product from Pulsatilla chinensis Regel.(In Vitro):Human articular chondrocytes and cartilage explants challenged with interleukin-1β (IL-1β) were treated with Anemonin. Anemonin treatment attenuated proteoglycan loss in human cartilage explants treated with IL-1β ex vivo. Anemonin delayed articular cartilage degeneration in vitro. (In Vivo):Destabilization of the medial meniscus (DMM) was performed in 10-week-old male C57BL/6J mice. Anemonin was then intra-articularly injected into the joint capsule for 8 and 12 weeks. Anemonin delayed articular cartilage degeneration in vivo. Anemonin decreased the expressions of matrix metalloproteinase-13 (MMP13), A disintegrin, and metalloproteinase with thrombospondin motifs 5 (ADAMTS5), collagen X (Col X) while increasing Aggrecan level in murine with DMM surgery. Proteoglycan loss and chondrocyte hypertrophy were significantly decreased in Anemonin-treated mice compared with vehicle-treated mice.

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Others

Other Targets

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90921-11-2

192.2

C10H8O4

>98% (HPLC)

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O=C1OC2(CCC22OC(=O)C=C2)C=C1

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(-20℃)

With Ice Pack

≥ 2 years