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Anagrelide
CAS No. 68475-42-3
Anagrelide( Agrelin | Agrylin | Anagrelide | Anagrelide | BL 4162A | Xagrid | Shire | Thromboreductin )
Catalog No. M15616 CAS No. 68475-42-3
Anagrelide is a Platelet-reducing Agent. The mechanism of action of anagrelide is as a Phosphodiesterase 3 Inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 140 | In Stock |
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| 10MG | 199 | In Stock |
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| 25MG | 311 | In Stock |
|
| 50MG | 480 | In Stock |
|
| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAnagrelide
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NoteResearch use only, not for human use.
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Brief DescriptionAnagrelide is a Platelet-reducing Agent. The mechanism of action of anagrelide is as a Phosphodiesterase 3 Inhibitor.
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DescriptionAnagrelide is a Platelet-reducing Agent. The mechanism of action of anagrelide is as a Phosphodiesterase 3 Inhibitor.
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In VitroCell Proliferation Assay Cell Line:Megakaryocytic and non-megakaryocytic cellsConcentration:0.05, 0.3, 1 μM Incubation Time:12-day Result:Inhibited only megakaryocytic cell growth at every concentration testedCell Cytotoxicity Assay Cell Line:GIST882 and GIST48 cell line Concentration:0.1, 1, 10, 100, 1000, 10000 nM Incubation Time:Result:Induced a cytotoxic effect in the GIST882 cell line (IC50= 16 nM), but was only weakly active in the GIST48 cell line.
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In VivoAnimal Model:Adult female athymic mice bearing GIST2B, GIST3, GIST9, GIST882 model Dosage:5 mg/kg Administration:Twice daily; for 10 days Result:Inhibited or reduced tumor growth in three (GIST2B, GIST9, GIST882) of these four models.
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SynonymsAgrelin | Agrylin | Anagrelide | Anagrelide | BL 4162A | Xagrid | Shire | Thromboreductin
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number68475-42-3
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Formula Weight256.09
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Molecular FormulaC10H7Cl2N3O
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM
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SMILESC1C2=C(C=CC(=C2Cl)Cl)NC3=NC(=O)CN31
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Chemical Name6,7-dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Venuti MC, et al. J Med Chem. 1988 Nov; 31(11): 2136-45.
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