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Amitifadine
CAS No. 410074-73-6
Amitifadine( DOV-21947 | EB-1010 )
Catalog No. M14408 CAS No. 410074-73-6
A triple monoamine reuptake inhibitor, inhibits the reuptake of 5-HT, norepinephrine and dopamine in HEK 293 cells with IC50 of 12, 23 and 96 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameAmitifadine
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NoteResearch use only, not for human use.
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Brief DescriptionA triple monoamine reuptake inhibitor, inhibits the reuptake of 5-HT, norepinephrine and dopamine in HEK 293 cells with IC50 of 12, 23 and 96 nM, respectively.
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DescriptionA triple monoamine reuptake inhibitor, inhibits the reuptake of 5-HT, norepinephrine and dopamine in HEK 293 cells with IC50 of 12, 23 and 96 nM, respectively; reduces the duration of immobility in the forced swim test in rats with an oral minimum effective dose (MED) of 5 mg/kg.Depression Phase 3 Clinical.
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In Vitro——
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In Vivo——
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SynonymsDOV-21947 | EB-1010
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PathwayMembrane Transporter/Ion Channel
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TargetMonoamine Transporter
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RecptorMonoamine Transporter
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Research AreaNeurological Disease
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IndicationDepression
Chemical Information
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CAS Number410074-73-6
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Formula Weight228.118
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Molecular FormulaC11H11Cl2N
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Purity>98% (HPLC)
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Solubility——
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SMILESC1C2C1(CNC2)C3=CC(=C(C=C3)Cl)Cl
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Chemical Name(1R,5S)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Skolnick P, et al. Eur J Pharmacol. 2003 Feb 14;461(2-3):99-104.
2. Warnock KT, et al. Pharmacol Biochem Behav. 2012 Nov;103(1):111-8.
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