Amgen-23( —— )

Catalog No. M35699 CAS No. 1448706-15-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Amgen-23
Note

Research use only, not for human use.
Brief Description

Amgen-23 is a selective and highly potent sphingosine kinase 1 (SPHK1) inhibitor that inhibits SPHK2 and can be used in anticancer research.
Description

Amgen-23 (compound 23) is a potent sphingosine kinases (SPHK) inhibitor with IC50 values of 20 nM and 1.6 μM for SPHK1 and SPHK2, respectively. Amgen-23 can be used for researching anticancer.
In Vitro

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In Vivo

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Synonyms

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Pathway

GPCR/G Protein
Target

S1P Receptor
Recptor

S1P Receptor
Research Area

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Indication

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CAS Number

1448706-15-7
Formula Weight

478.44
Molecular Formula

C23H25Cl2N3O2S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (209.02 mM; Ultrasonic )
SMILES

N(C1=NC(=CS1)C2=CC(Cl)=C(Cl)C=C2)C3=CC=C(CCN4[C@@H](CO)C[C@@H](O)CC4)C=C3
Chemical Name

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1. Gustin DJ, et al. Structure guided design of a series of sphingosine kinase (SphK) inhibitors. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4608-16.?

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