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Alsteropaullone
CAS No. 237430-03-4
Alsteropaullone ( 9-Nitropaullone;NSC 705701 )
Catalog No. M13686 CAS No. 237430-03-4
Alsteropaullone (9-Nitropaullone, NSC 705701) is a derivative of kenpaullone, ATP-competitive inhibitor of CDKs and GSK3β, inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E and Cdk5/p25 with IC50 of 35, 15, 200 and 40 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 192 | In Stock |
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| 10MG | 309 | In Stock |
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| 25MG | 525 | In Stock |
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| 50MG | 752 | In Stock |
|
| 100MG | 1035 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAlsteropaullone
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NoteResearch use only, not for human use.
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Brief DescriptionAlsteropaullone (9-Nitropaullone, NSC 705701) is a derivative of kenpaullone, ATP-competitive inhibitor of CDKs and GSK3β, inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E and Cdk5/p25 with IC50 of 35, 15, 200 and 40 nM.
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DescriptionAlsteropaullone (9-Nitropaullone, NSC 705701) is a derivative of kenpaullone, ATP-competitive inhibitor of CDKs and GSK3β, inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E and Cdk5/p25 with IC50 of 35, 15, 200 and 40 nM; exhibits specific antitumor activity against Group 3 medulloblastomas, causes inhibition of cell cycle-related genes, and down-regulation of MYC; inhibits the cytosolic degradation of β-catenin to alter the canonical Wnt signaling pathway in primary axis patterning, reduces tau phosphorylation.
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Synonyms9-Nitropaullone;NSC 705701
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number237430-03-4
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Formula Weight293.30
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Molecular FormulaC16H11N3O3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1NC2=CC=CC=C2C(NC3=C4C=C([N+]([O-])=O)C=C3)=C4C1
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Chemical Name7,12-dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Soni DV, et al. Cell Cycle. 2004 Mar;3(3):349-57.
2. Lahusen T, et al. Mol Carcinog. 2003 Apr;36(4):183-94.
3. Schultz C, et al. J Med Chem. 1999 Jul 29;42(15):2909-19.
4. Faria CC, et al. Oncotarget. 2015 Aug 28;6(25):21718-29.
2. Lahusen T, et al. Mol Carcinog. 2003 Apr;36(4):183-94.
3. Schultz C, et al. J Med Chem. 1999 Jul 29;42(15):2909-19.
4. Faria CC, et al. Oncotarget. 2015 Aug 28;6(25):21718-29.
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