Alsteropaullone

CAS No. 237430-03-4

Alsteropaullone ( 9-Nitropaullone;NSC 705701 )

Catalog No. M13686 CAS No. 237430-03-4

Alsteropaullone (9-Nitropaullone, NSC 705701) is a derivative of kenpaullone, ATP-competitive inhibitor of CDKs and GSK3β, inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E and Cdk5/p25 with IC50 of 35, 15, 200 and 40 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 192 In Stock
10MG 309 In Stock
25MG 525 In Stock
50MG 752 In Stock
100MG 1035 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Alsteropaullone
  • Note
    Research use only, not for human use.
  • Brief Description
    Alsteropaullone (9-Nitropaullone, NSC 705701) is a derivative of kenpaullone, ATP-competitive inhibitor of CDKs and GSK3β, inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E and Cdk5/p25 with IC50 of 35, 15, 200 and 40 nM.
  • Description
    Alsteropaullone (9-Nitropaullone, NSC 705701) is a derivative of kenpaullone, ATP-competitive inhibitor of CDKs and GSK3β, inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E and Cdk5/p25 with IC50 of 35, 15, 200 and 40 nM; exhibits specific antitumor activity against Group 3 medulloblastomas, causes inhibition of cell cycle-related genes, and down-regulation of MYC; inhibits the cytosolic degradation of β-catenin to alter the canonical Wnt signaling pathway in primary axis patterning, reduces tau phosphorylation.
  • Synonyms
    9-Nitropaullone;NSC 705701
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    237430-03-4
  • Formula Weight
    293.30
  • Molecular Formula
    C16H11N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1NC2=CC=CC=C2C(NC3=C4C=C([N+]([O-])=O)C=C3)=C4C1
  • Chemical Name
    7,12-dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Soni DV, et al. Cell Cycle. 2004 Mar;3(3):349-57.
2. Lahusen T, et al. Mol Carcinog. 2003 Apr;36(4):183-94.
3. Schultz C, et al. J Med Chem. 1999 Jul 29;42(15):2909-19.
4. Faria CC, et al. Oncotarget. 2015 Aug 28;6(25):21718-29.
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