Alpha-Hederin( alpha-Hederin )

Catalog No. M18339 CAS No. 27013-91-8

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HNMR

HPLC

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Product Name

Alpha-Hederin
Note

Research use only, not for human use.
Brief Description

Alpha-hederin is a water-soluble pentacyclic triterpenoid saponin found in the seeds of Nigella sativa, with hemolytic and apoptotic properties.
Description

alpha-Hederin is Derived from beta-amyrin; other hederigenin based saponins are available. It induces apoptosis in hepatocellular carcinoma cells.(In Vitro):alpha-Hederin (α-Hederin) is cytotoxic and inhibits proliferation in both cel lines at rather low concentrations. alpha-Hederin (α-Hederin)reduces the mitotic activity in treated cells.(In Vivo):alpha-Hederin (α-Hederin) has preventive effect on sensitized rats like thymoquinone. It may intervene in miRNA-126 expression, which consequently could interfere with IL-13 secretion pathway leading to a reduction in inflammatory responses.
In Vitro

alpha-Hederin (α-Hederin) is cytotoxic and inhibits proliferation in both cel lines at rather low concentrations. alpha-Hederin (α-Hederin)reduces the mitotic activity in treated cells.
In Vivo

alpha-Hederin (α-Hederin) has preventive effect on sensitized rats like thymoquinone. It may intervene in miRNA-126 expression, which consequently could interfere with IL-13 secretion pathway leading to a reduction in inflammatory responses.
Synonyms

alpha-Hederin
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Others-Field
Indication

——

CAS Number

27013-91-8
Formula Weight

750.97
Molecular Formula

C41H66O12
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 100 mg/mL 133.16 mM; H2O : < 0.1 mg/mL
SMILES

C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]1[C@H]([C@H](CO[C@H]1O[C@H]1CC[C@]2([C@H]([C@]1(C)CO)CC[C@@]1([C@@H]2CC=C2[C@]1(CC[C@@]1([C@H]2CC(CC1)(C)C)C(=O)O)C)C)C)O)O)O)O)O
Chemical Name

(4alpha)-3beta-((2-O-(6-Deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinopyranosyl)oxy)-23-hydroxyolean-12-en-28-oic acid

1. Randhawa MA, et al. Am J Chin Med. 2011;39(6):1075-91.

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