Aloperine( Aloperine )

Catalog No. M18812 CAS No. 56293-29-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Aloperine
Note

Research use only, not for human use.
Brief Description

Aloperine exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.
Description

Aloperine is an alkaloid with diverse biological activities including antiviral, anticancer, antioxidant, and anti-inflammatory actions. It inhibits HIV-1 replication and envelope-mediated cell-cell fusion in vitro. Aloperine also inhibits the growth of HL-60, U937, and K562 leukemia cell lines.
In Vitro

Aloperine (1-20 μM; 24 hours) gives growth-inhibitory IC50 values in cancer cells ranges from 0.04 to 1.36 mM, the IC50 values in HL-60, U937, K562, EC109, A549 and HepG2 cells are 0.04, 0.27, 0.36, 1.11, 1.18 and 1.36 mM,respectively.Aloperine (1-20 μM; 24 hours) induces apoptosis and decreases bcl-2 expression in HL-60 cells.Aloperine (20–100 μM; 18 hours) induces autophagy and formation of acidic vacuole in HL-60 cells.
In Vivo

——
Synonyms

Aloperine
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Others-Field
Indication

——

CAS Number

56293-29-9
Formula Weight

232.36
Molecular Formula

C15H24N2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 5.56 mg/mL (23.93 mM)
SMILES

C1CCN2C[C@H]3C[C@@H]([C@H]2C1)C=C1[C@H]3NCCC1
Chemical Name

(6R,6aR,13R,13aS)-1,3,4,6,6a,7,8,9,10,12,13,13a-dodecahydro-2H-6,13-methanodipyrido[1,2-a:3',2'-e]azocine

1. Yuan XY, et al. Eur J Pharmacol, 2010, 629(1-3), 147-152.

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