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Alloxazine

CAS No. 490-59-5

Alloxazine( —— )

Catalog No. M27527 CAS No. 490-59-5

Alloxazine (Isoalloxazine) is an A2 receptor antagonist, which is approximately 10-fold more selective for the A2B receptor than for the A2A receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Alloxazine
  • Note
    Research use only, not for human use.
  • Brief Description
    Alloxazine (Isoalloxazine) is an A2 receptor antagonist, which is approximately 10-fold more selective for the A2B receptor than for the A2A receptor.
  • Description
    Alloxazine (Isoalloxazine) is an A2 receptor antagonist, which is approximately 10-fold more selective for the A2B receptor than for the A2A receptor.
  • In Vitro
    Alloxazine (0-30 μM, 20 min) inhibits cyclic AMP production in PGT-β cells. Cell Viability Assay Cell Line:PGT-β cells Concentration:0-30 μM Incubation Time:20 min Result:Inhibited the cyclic AMP generation concentration-dependently with an IC50 of 2.9 μM.
  • In Vivo
    Alloxazine (1 μmol/L; cortical surface suffusion for 0-20 min) suppresses NECA-induced vasodilation. Animal Model:Male Sprague-Dawley rats Dosage:1 μmol/L Administration:Cortical surface suffusion; 1 μmol/L once Result:Significantly suppressed vasodilation with increased EC25 value of 0.60 μmol/L.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    glucokinase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    490-59-5
  • Formula Weight
    214.184
  • Molecular Formula
    C10H6N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 5 mg/mL (23.34 mM)
  • SMILES
    O=c1[nH]c2nc3ccccc3nc2c(=O)[nH]1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dzyurkevich MS, et al. Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus. Sci Rep. 2017 Nov 22;7(1):16072.
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