Alfacalcidol ( 1-hydroxycholecalciferol; 1.alpha.-Hydroxyvitamin D3 )

Catalog No. M17506 CAS No. 41294-56-8

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Product Name

Alfacalcidol
Note

Research use only, not for human use.
Brief Description

Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator medication.
Description

Alfacalcidol is an active metabolite of Vitamin D, which performs important functions in regulation of the calcium balance and the bone metabolism. Alfacalcidol is Vitamin D-hormone analog which is activated by the enzyme 25-hydroxylase in the liver for systemic and in osteoblasts for local D-hormone actions. It possesses a unique pattern of pleiotropic effects on, e.g. gut, bone, pararthyroids, muscle and brain. Alfacalcidol is superior to plain vitamin D (cholecalciferol) because the final kidney activation of the latter is regulated by a negative feedback mechanism.
Synonyms

1-hydroxycholecalciferol; 1.alpha.-Hydroxyvitamin D3
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Metabolic Disease
Indication

——

CAS Number

41294-56-8
Formula Weight

400.64
Molecular Formula

C27H44O2
Purity

98%
Solubility

DMSO : ≥ 50 mg/mL. 124.80 mM; H2O : < 0.1 mg/mL
SMILES

[H][C@@]12CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CCC\C2=C\C=C1/C[C@@H](O)C[C@H](O)C1=C
Chemical Name

(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol

1.Munisamy S, Daud KM, Mokhtar SS, Rasool AH.Microcirculation. 2016 Jan;23(1):53-61.

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