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Ajmalicine
CAS No. 483-04-5
Ajmalicine( Raubasine | Delta-Yohimbine | Ajmalicin | Lamuran )
Catalog No. M28573 CAS No. 483-04-5
Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, IC50 = 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity。
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 151 | In Stock |
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| 5MG | 255 | In Stock |
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| 10MG | 380 | In Stock |
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| 25MG | 619 | In Stock |
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| 50MG | 861 | In Stock |
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| 100MG | 1161 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAjmalicine
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NoteResearch use only, not for human use.
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Brief DescriptionAjmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, IC50 = 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity。
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DescriptionAjmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, IC50 = 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity。(In Vitro):Ajmalicine preferentially blocks α1-adrenoceptor than α2-adrenoceptor. Ajmalicine inhibits contractions in a concentration-dependent manner, IC50=72.3 ± 22.5 μM. Ajmalicine acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2.(In Vivo):Ajmalicine blocks the pressor action of electrical stimulation and is active against sympathetic stimulation. Ajmalicine (0.5-4 mg/kg) induces a marked dose-dependent inhibition against the pressor response to noradrenaline.
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In VitroAjmalicine preferentially blocks α1-adrenoceptor than α2-adrenoceptor.Ajmalicine inhibits contractions in a concentration-dependent manner (IC50=72.3 ± 22.5 μM).Ajmalicine acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2.
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In VivoAjmalicine blocking the pressor action of electrical stimulation and is active against sympathetic stimulation.Ajmalicine (0.5-4 mg/kg) induces a marked dose-dependent inhibition against the pressor response to noradrenaline. Animal Model:Male Wistar rats (300-350 g)Dosage:0.5, 1, 2, and 4 mg/kg Administration:IV, once Result:Induced a marked dose-dependent inhibition against the pressor response to noradrenaline.
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SynonymsRaubasine | Delta-Yohimbine | Ajmalicin | Lamuran
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PathwayAngiogenesis
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TargetAdrenergic Receptor
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Recptorp53
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Research Area——
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Indication——
Chemical Information
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CAS Number483-04-5
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Formula Weight352.43
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Molecular FormulaC21H24N2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5.56 mg/mL (15.78 mM)
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SMILES[H][C@@]12C[C@]3([H])C(=CO[C@@H](C)[C@@]3([H])CN1CCc1c2[nH]c2ccccc12)C(=O)OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Choudhary A, et al. Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer. Mol Cancer Ther. 2016 Jan;15(1):48-59.
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