Agnuside ( chasteberry oil )

Catalog No. M19869 CAS No. 11027-63-7

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Product Name

Agnuside
Note

Research use only not for human use.
Brief Description

Agnuside inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3 66.8 and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5 25 and 100 μM respectively.
Description

Agnuside inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3 66.8 and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5 25 and 100 μM respectively.
Synonyms

chasteberry oil
Pathway

Chromatin/Epigenetic
Target

COX
Recptor

COX-2; P-gp?(P-glycoprotein)
Research Area

——
Indication

——

CAS Number

11027-63-7
Formula Weight

466.44
Molecular Formula

C22H26O11
Purity

>98% (HPLC)
Solubility

DMSO: 10 mg/mL
SMILES

OC[C@H]1O[C@@H](O[C@@H]2OC=C[C@H]3[C@H](O)C=C(COC(=O)c4ccc(O)cc4)[C@@H]23)[C@H](O)[C@@H](O)[C@@H]1O
Chemical Name

[(1S4aR5S7aS)-5-Hydroxy-1-[(2S3R4S5S6R)-345-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-14a57a-tetrahydrocyclopenta[c]pyran-7-yl]methyl 4-hydroxybenzoate

1.Suksamrarn A et al. Iridoids with anti-inflammatory activity from Vitex peduncularis. Planta Med. 2002 Jan;68(1):72-3.

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