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Aegeline

CAS No. 456-12-2

Aegeline( —— )

Catalog No. M21098 CAS No. 456-12-2

Aegeline is an alkaloidal-amide isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Aegeline
  • Note
    Research use only, not for human use.
  • Brief Description
    Aegeline is an alkaloidal-amide isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus.?
  • Description
    Aegeline is an alkaloidal-amide isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus.?
  • In Vitro
    Aegeline also prevents growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein or Bax-expressing cells.Aegeline shows weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    456-12-2
  • Formula Weight
    297.3
  • Molecular Formula
    C18H19NO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (336.30 mM)
  • SMILES
    COc1ccc(C(O)CNC(=O)/C=C/c2ccccc2)cc1
  • Chemical Name
    N-[2-hydroxy-2(4-methoxyphenyl) ethyl]-3-phenyl-2-propenamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Aegeline from Aegle marmelos stimulates glucose transport via Akt and Rac1 signaling and contributes to a cytoskeletal rearrangement through PI3K/Rac1[J]. European Journal of Pharmacology 2015 762:419-429.
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