Adjudin

CAS No. 252025-52-8

Adjudin ( AF-2364; AF 2364; AF2364; Adjudin )

Catalog No. M17455 CAS No. 252025-52-8

Adjudin is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.

Purity : 97%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 43 In Stock
10MG 68 In Stock
25MG 105 In Stock
50MG 141 In Stock
100MG 214 In Stock
500MG 536 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Adjudin
  • Note
    Research use only, not for human use.
  • Brief Description
    Adjudin is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.
  • Description
    Adjudin, also known as AF-2364, is a drug which is under development as a potential non-hormonal male contraceptive drug, which acts by blocking the production of sperm in the testes, but without affecting testosterone production. It is an analogue of the chemotherapy drug lonidamine, an indazole-carboxylic acid, and further studies continue to be conducted into this family of drugs as possible contraceptives. A study in 2013 indicated that Adjudin, similar to its analogue lonidamine, has properties that inhibit cancer growth by targeting mitochondria and blocking energy metabolism in certain kinds of tumor cells in mice, indicating that it has potential as a drug for cancer therapy.
  • Synonyms
    AF-2364; AF 2364; AF2364; Adjudin
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    252025-52-8
  • Formula Weight
    335.19
  • Molecular Formula
    C15H12Cl2N4O
  • Purity
    97%
  • Solubility
    DMSO : ≥ 34 mg/mL; 101.44 mM
  • SMILES
    Clc1c(Cn2nc(c3c2cccc3)C(=O)NN)ccc(Cl)c1
  • Chemical Name
    1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mruk DD. Trends Endocrinol Metab. 2008 Mar;19(2):57-64.
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