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Ademetionine(b)

CAS No. 29908-03-0

Ademetionine(b)( S-Adenosyl-L-methionine | S-Adenosyl methionine | SAMe | AdoMet )

Catalog No. M20824 CAS No. 29908-03-0

Ademetionine is an intermediate metabolite of methioninefor treatment of primary biliary cirrhosis and major depressive disorder.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ademetionine(b)
  • Note
    Research use only, not for human use.
  • Brief Description
    Ademetionine is an intermediate metabolite of methioninefor treatment of primary biliary cirrhosis and major depressive disorder.
  • Description
    Ademetionine is an intermediate metabolite of methioninefor treatment of primary biliary cirrhosis and major depressive disorder.
  • In Vitro
    Apoptosis Analysis Cell Line:Cal-33 and JHU-SCC-011 cells Concentration:300 μM Incubation Time:24 h (Cal-33) or 48 h (HU-SCC-011)Result:Showed an approximately 10% and 3%of apoptotic cells respectively.Cell Cycle Analysis Cell Line:Cal-33 and JHU-SCC-011 cells Concentration:300 μM Incubation Time:24 h (Cal-33) or 48 h (HU-SCC-011)Result:Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.
  • In Vivo
    Animal Model:Valproic acid treated young mice Dosage:30?mg/kg Administration:p.o., for 3 days Result:Alleviated most ASD like neurobehavioral symptoms.Normalized the redox potential in the prefrontal cortex.
  • Synonyms
    S-Adenosyl-L-methionine | S-Adenosyl methionine | SAMe | AdoMet
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Neurological Disease
  • Indication
    Major depressive disorder

Chemical Information

  • CAS Number
    29908-03-0
  • Formula Weight
    398.44
  • Molecular Formula
    C15H22N6O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (250.98 mM);H2O:43 mg/mL (107.92 mM)
  • SMILES
    C[S+](CCC(N)C(=O)[O-])CC1OC(n2cnc3c(N)ncnc32)C(O)C1O
  • Chemical Name
    (2S)-2-amino-4-((((2S3S4R5R)-5-(6-amino-9H-purin-9-yl)-34-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)sulfonio)butanoate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ivashkin V T Maevskaya M V Kobalava Z D et al. Open-label study of ademetionine for the treatment of intrahepatic cholestasis associated with alcoholic liver disease.[J]. Minerva Gastroenterologica E Dietologica 2018.
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