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Adaphostin
CAS No. 241127-58-2
Adaphostin( NSC 680410 | 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate )
Catalog No. M27602 CAS No. 241127-58-2
Adaphostin is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 58 | Get Quote |
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| 10MG | 87 | Get Quote |
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| 25MG | 178 | Get Quote |
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| 50MG | 295 | Get Quote |
|
| 100MG | 444 | Get Quote |
|
| 500MG | 963 | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameAdaphostin
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NoteResearch use only, not for human use.
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Brief DescriptionAdaphostin is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.
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DescriptionAdaphostin is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.(In Vitro):It also induces apoptosis in T-lymphoblastic human leukemia cell lines with IC50 ranging from 16.8 to 216.3 nM in vitro.(In Vivo):Adaphostin can damage both myeloid and lymphoid leukemia cells.
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In VitroAdaphostin down-regulates p210bcr/abl in K562 cells and inhibits granulocyte colony formation in chronic myelogenous leukemia (CML) specimens at lower concentrations without enhanced toxicity in normal progenitors.Adaphostin-induced p53 up-regulation, DNA strand breaks, and ROS production in ML-1 cells is inhibited by N-acetylcysteine (NAC).
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In Vivo——
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SynonymsNSC 680410 | 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate
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PathwayAngiogenesis
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TargetBcr-Abl
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RecptorCyclophilin J
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Research Area——
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Indication——
Chemical Information
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CAS Number241127-58-2
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Formula Weight393.483
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Molecular FormulaC24H27NO4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (127.07 mM)
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SMILESOc1ccc(O)c(CNc2ccc(cc2)C(=O)OC23CC4CC(CC(C4)C2)C3)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Zhao X, et al. Cyclophilin J PPIase Inhibitors Derived from 2,3-Quinoxaline-6 Amine Exhibit Antitumor Activity. Front Pharmacol. 2018 Feb 21;9:126.
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