Acetylhydroquinone

Research use only, not for human use.

1. 2, 5-Dihydroxyacetophenone possess anti-anxiety, and neuroprotective qualities. 2. 2, 5-Dihydroxyacetophenone treatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPKs.

2, 5-Dihydroxyacetophenone possess anti-anxiety, and neuroprotective qualities. 2, 5-Dihydroxyacetophenone treatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPKs, it also can potentiate the pro-apoptotic and anti-proliferative effects of bortezomib in U266 cells. 2, 5-Dihydroxyacetophenone has anti-inflammatory activity in activated macrophages, raising the possibility that this compound has a therapeutic potential for inflammatory conditions. 2, 5-Dihydroxyacetophenone is an uncompetitive inhibitor of murine tyrosinase (K(I) 0.28mm), it strongly inhibits both melanogenesis and cellular tyrosinase activity in vitro in 3-isobutyl-1-methylxanthin-stimulated B16 mouse melanoma cells or in vivo in zebrafish and mouse models.

2,5-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression and significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 via the down-regulation of their mRNA expression in LPS-stimulated RAW264.7 cells. 2,5-Dihydroxyacetophenone potently inhibits the phosphorylation of extracellular signal-related kinase (ERK) 1/2 and the nuclear translocation of nuclear factor-κB (NF-κB) p65 in LPS-stimulated cells.

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Others

Other Targets

Tyrosinase

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490-78-8

152.14

C8H8O3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (657.25 mM)

CC(=O)C1=C(C=CC(=C1)O)O

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(-20℃)

With Ice Pack

≥ 2 years