Acebilustat ( CTX-4430;EP-501 )

Catalog No. M16760 CAS No. 943764-99-6

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Product Name

Acebilustat
Note

Research use only, not for human use.
Brief Description

Acebilustat (CTX-4430, EP-501)is a potent and selective leukotriene A4 hydrolase (LTA4H) inhibitor with IC50 of 64 nM for inhibition of LTB4 production in human whole blood.
Description

Acebilustat (CTX-4430, EP-501)is a potent and selective leukotriene A4 hydrolase (LTA4H) inhibitor with IC50 of 64 nM for inhibition of LTB4 production in human whole blood; a new once‐daily oral antiinflammatory drug in development for treatment of cystic fibrosis (CF) and other diseases.Cystic Fibrosis,Phase 2 Clinical
Synonyms

CTX-4430;EP-501
Pathway

Others
Target

Other Targets
Recptor

LTB4
Research Area

Other Indications
Indication

Fibrosis

CAS Number

943764-99-6
Formula Weight

481.54
Molecular Formula

C29H27N3O4
Purity

>98% (HPLC)
Solubility

10 mM in DMSO; Methanol: ≥ 32 mg/mL
SMILES

O=C(O)C1=CC=C(CN2[C@](C3)([H])CN(CC4=CC=C(OC5=CC=C(C6=NC=CO6)C=C5)C=C4)[C@]3([H])C2)C=C1
Chemical Name

Benzoic acid, 4-[[(1S,4S)-5-[[4-[4-(2-oxazolyl)phenoxy]phenyl]methyl]-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]-

1. Elborn JS, et al. Clin Transl Sci. 2017 Jan;10(1):20-27.
2. Elborn JS, et al. Clin Transl Sci. 2017 Jan;10(1):28-34.

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